Southeast Ohio includes rural areas of the state that border West Virginia. This region is very hilly as it lies in the foothills of the Appalachian Mountains. Most of the Wayne National Forest is in Southeast Ohio. When looking at a map, the forest will look like patches. The whole area resembles the National Forest, which is reclaimed strip mining areas, in various stages of reforestation. Much of it is primative area, popular with hunters and all terrain vehicle users. The southeastern part is along the banks of the Ohio River and has some of Ohio's most scenic and historic areas.
Southeastern Ohio does not have any big cities, but does have a whole bunch of small towns.
This is coal mining country. The landscape is generally composed of the foothills of the Appalachian Mountain Range. Altough this is a beautiful area of Ohio and depending on how deeply you penetrate this area, you may find it a bit unusal, compared to other parts of Ohio. This is the fringe of the Appalachian area, where things like "talking in tounges" and handling poisonous snakes at religious events become more common. Many of the residents are deeply religous, with mixed heritages that include native Americans and Secret People (Melungeons) . They have ways that are a little different. If you are in the cities, this will not be as evident, as in the more primative, or at best rural areas. As far as the people go, they likely are as harmless as any other Ohioans. The area is tremendously rough with 200 foot drops in elevation being common. Some unimproved, likely private roads (In most cases, the owners of the Wayne National Forest land, retained ownership of the mineral rights, with restrictions.), end at "drops". Drops, to some cliffs, are where the road ends and the strip mine begins, or where trucks back up to dump refuse. There are no signs marking these dangers and driving after dark, off road is at best dangerous.
I-77 runs north-west through this region. I-70 runs east-west along the northern portion of the region.
This is a very rural part of Ohio with many primative areas. As long as you stay on the paved, narrow, winding roads, you should have few problems. If you wander off onto the logging or coal mine roads, be prepared for potholes, bad roads, mud and very little, if any traffic to ask for assitance. Much of this area is not served by cell phone towers and you will have no communications. The area is popular with hunters and all terrain vehicle users. Rumor has it that the area is also popular with marijuana growers, in and out of the Wayne National Forest. If you come upon a patch, change direction and move on slowly while looking for man-traps. Don't even think about getting close enough to pick any. You may be, being video taped by law enforcement, or worse. During hunting season, wear brightly-colored clothing if you go into the woods.