By car, Portsmouth can be accessed using U.S. Route 23 (North/South) and U.S. Route 52 (East/West). Greyhound serves Portsmouth as well. By boat, Portsmouth can be accessed by using the Ohio River. By Canoe, Portsmouth can be accessed using the Scioto River. By Plane, Portsmouth can be accessed through the Portsmouth Regional Airport located in nearby Minford.
Other than a couple cab companies, there are no forms of public transit. Although, a traveler can easily walk to many locations downtown.
Portsmouth is full of history so take time to visit the antique shops, cafes and pubs in the Bonneyfiddle District. One of the main attractions in Portsmouth is the 1,000 foot floodwall mural painted by famed artist Robert Dafford. It is truly amazing and quite unique.
The World Championship of Cornhole takes place each summer in the nearby Village of South Webster. Teams from around the state and country visit the area on this weekend to take place in this popular sport. Also held each year is the Southern Ohio Machine Gun Shoot in Minford. Owners of machineguns and spectators gather in June to fire these historic and exotic weapons.
The Ramada Inn is located right downtown near the river. Other chain hotels are located in the north side of the city and in nearby Wheelersburg, east of Portsmouth.