The Mont-Blanc was first climbed by Jacques Balmat and Dr. Michel Paccard in 1786, and the next year by H.-B. de Saussure.
Ascension by foot
Although climbing the Mont-Blanc is not technically very difficult, the altitude requires proper training and equipment. A mountain guide is quite necessary unless you already know the place.
Usually done from Saint-Gervais-les-Bains with a night in the Goûter refuge.
Ascension by ski
Climbing the Mont-Blanc by ski is reserved for highly trained skiers. It's mostly glacier skiing. It can be done from March to June, depending of the snow falled during the winter. A mountain guide is quite necessary unless you already know the place.
Usually done from Chamonix with a night in the Grands Mulets refuge.