Lier can be conveniently reached by car. Highways aren't that close. It's halfway between E19 ( Antwerp to Brussels ) and E313 ( Antwerpto Liege. The National roads connected the town with the highways and other close by cities, like the N10 to Antwerp, N14 to Mechelen and N13 to the E313. Like many towns in Belgium it's a problem though to get rid of your car in the center.
The public transport company De Lijn  has a number of bus lines through Lier.
Best method to discover Lier. Most places of interest are in the center of the city and lay only a couple of minutes from each other.
Most of the nightlife is centered around Zimmerplein in local pubs.