Starting at New Orleans you will go east on I-10 for approximately 70 miles, you will cross into Mississippi. Get off I-10 at Exit 34A and merge onto US-49. This trip will take you about an hour and a half.
If starting at Mississippi's capital Jackson - Get on US-49 S at exit 47 A heading towards Richland/Hattisburg. Then merge onto I-59 S towards New Orleans/Gulf Coast. You will then merge again onto US-98 E at Exit 59, then take the US-49 exit heading towards Gulfport. Merge again onto US-49 S in the direction of Gulfport. This trip will take you about 3 hours.
To get around Gulfport you could rent a car. There are multiple car rental businesses located right at the Gulfport-Biloxi International Airport. Including Avis, Budget, Hertz, National and Thrifty. There are also taxi and limousine services, along with shuttles that will take you to and from your hotel.
You can go and see the white sanded coastal beaches that look over the Gulf of Mexico. These beaches are viewable from Beach Boulevard (U.S. Highway 90) there are plenty of places along the highway where you can pull over for picture opportunities.
Gulfport is famous for it's seafood, fresh seafood is bought from the ports every morning including shrimp, snapper, tuna,flounder and grouper. Gulfport also has many Cajun, Southern and Interantional restaurants that will suite every taste and help make your trip to Gulfport exciting.
Daddy's Little Kitchen #1, 2605 25th Avenue, (228) 822-0212. M-F 5:30AM–4PM; Sa,Su 5:30AM–2:30PM. a locally owned restaurant specializing in breakfast and lunch. Their Po Boys in particular are exceptional.
Catfish Charlie’s, 11419 Canal Road, (228) 832-9195. Th–Sa 5PM-9PM. Specializes in fried and flaky catfish, their chicken and sidedishes are good too. They are known for their down south, family atmosphere.
Lookout 49, 12013 Highway 49, (228) 328-1366. was originally located in the Long Beach Harbor and went by the name of Long Beach Look Out, but then some ill weather took it down, so they have moved to a new location. It is the local favorite for spectacular seafood, steaks & specialties. They are also famous for their Sweet potato Bread Pudding with Whiskey Sauce.
Emeril's Gulf Coast Fish House, 3300 West Beach Blvd, Phone: (228) 314-1515. Lunch: M-F 11:30AM-2PM; Dinner: Su-Th 5:30PM-10PM; F,Sa 5:30PM-11PM. Located inside the Island View Casino Resort, they supply a large amount of southern sea selections and are also known for their delicious desserts.
Tug's Wharf, 1458 Magnolia Street, (228) 604-2233. M-F 11am-9pm; Sa,Su 11AM-10PM. “Gulf Coast Seafood The Way It Used To Be!” - They offer steaks, traditional Cajun cuisine, gumbo and etoufee. They use only seafood that has been caught on that day, ensuring the freshest ingredients