George can be reached easily with the N2 highway from Cape Town or Port Elizabeth and Durban.
George has its own airport. South African Airways operates flights to major cities in South Africa, like Cape Town, Johannesburg and Durban. Low-fare airlines 1Time, Kulula.com and Nation Wide provide cheap flights to and from Johannesburg.
The main bus companies serve George regularly on their way along the Garden Route from Cape Town to Port Elizabeth as does the Baz bus.
Preferably by car :). York street is the main artery. Watch out for the ubiquitous speeding traps.
There are numerous fine drinking and dining holes along this stretch of the Garden Route. Bongos in Wilderness village overlooks the lovely beach.