Termiz is right along the border with Afghanistan. You can see Afghanistan across the river from various points on the roads around the town.
Old Termiz dates back to the 6th century BC, was conquered by Alexander the Great and was an early center of Buddhism. In later times it was a center of Islam and was later destroyed by Genghis Khan.
Modern Termiz was built a few kilometres away and is currently a major supply hub for the NATO war operations in Afghanistan. It is also a busy transport hub for goods entering and leaving Afghanistan due to the Friendship Bridge, built by the Soviet Union.
There is a night train from Tashkent every second day, leaving Tashkent Pass Csentr. at 9 PM and arriving next day at 11:40 AM.
Coming from Afghanistan, it is possible to take a shared taxi or drive to Hairatan on the other side of the river and then walk across the border.