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There are very few flights to [[Santa Elena de Uairén]]. [[Rutaca_Airlines|Rutaca]] is the only airline that services the town with any regularity from Ciudad Bolívar and Puerto Ordaz. You should contact the airline at the Ciudad Bolívar Airport (58-285) 632-4465 / 632-8426 to find out more information about the flights. They should direct you with information on how to book.
Night buses go to Santa Elena from [[Ciudad Bolivar]], [[Puerto Ordaz]], Maturin and Puerto la Cruz in Venezuela and from Boa Vista [[Boa Vista]] in Brazil. There are also buses that go direct from Caracas Terminal de Oriente (22 hour trip). Bus companies that do the route are Expresos Los Llanos, Expreso Occidente, and a state owned company with red
If you take a bus please understand that the buses are cold and drivers refuse to raise the temperature. Bus temperatures average around 7ºC (45ºF).