South Texas Plains
Texas's southern region is, for the most part, a forbidding desert area. A borderland with nearby Mexico, it acts as a gateway for those coming North and those going South. It's also very warm, even in the winter, so many people come from the north to warm up here.
Wear sun screen and a hat as the sun is very repressive in the summer months. Be cautious when traveling near the border, avoid any unofficial roads or trails, stay away from dimly lit areas at night, and DO NOT pick up any hitchhikers. Overall, the cities and towns in South Texas are fairly safe, a lot safer than anywhere in Mexico and even safer than a lot of areas in Dallas and Houston.