Escambray,  is the local periodical.
There is an overnight train to/from Havana on alternate days, and there may be a (very) early morning train to Santa Clara and Cienfuegos that returns in the afternoon. Sancti Spiritus is not on the main line. Check that the trains are running in advance.
There are very few taxis in Sancti Spiritus, but horse carts and bicycle-taxis are all over. Horse carts wait outside the bus terminal and leave when full to the Parque Serafin Sanchez in the historical centre of the city.
Sights in Sancti Spiritus include:
Take a walk through the historical centre of the city, starting from the train station in the south and ending at the Parque Maceo in the north.
There are two hotels in Sancti Spiritus -- the Hostal del Rijo off the Plaza Honorato and the Hotel Plaza off the Parque Serafin Sanchez. Both are in historical colonial buildings.
There are about two dozen casa particulares to choose from. Touts will meet all incoming buses and happily escort you to a casa.