The Palouse is a region of Washington.
- Spokane — largest city in eastern Washington and third-largest in the Pacific Northwest Region; county seat of Spokane County  and home to Gonzaga University
- Colfax — county seat of Whitman County
- Pullman — home of Washington State University
- Dayton — county seat of Columbia County
- Pomeroy — county seat of Garfield County
- Asotin — county seat of Asotin County
- Hooper — Once thriving, now a ghost town. It was built by the McGregor Company based on the sheep-raising industry. In Whitman County, on the Palouse River just south of Highway 26, between Washtucna and Pampa.
For our purposes, the Palouse consists of Spokane, Whitman, Columbia, Garfield, and Asotin counties. Portions of adjacent North Central Idaho are often included in the broader region.
Spokane International Airport, located in the region, offers air service to some cities in the western US: see the Spokane article for details. Other airports with commercial air service near this region include Walla Walla, Pasco and Pullman. The nearest major international airports are Seattle-Tacoma International Airport or Portland International Airport, but they are 5-6 hours away by car.
Amtrak's Empire Builder stops at Spokane: this is the only train service to this region.
Major east-west routes through this region arre I-90 through Spokane and US-12 through the southern areas. US-195 is a major north-south route.
- The Snake River Canyon carries the Snake River through the Palouse from Lewiston, Idaho, through an arc northwest then southwest, and finally empties it into the Columbia River at Burbank, near Pasco. The most popular site is just SW of Pullman near Lower Granite Dam. However, you cannot follow the river by car any further downstream. Due to the extensive backtracking that would be required, most people are only able to view one section of the canyon per road trip.
- Spokane House Interpretive Center, N Riverside Park Dr. (via Nine Mile Rd. - WA Hwy 291), Nine Mile Falls, WA, ☎ +1-(509) 465-5064, . summer: Sat 14-16h, Sun 10-16h, other times by arrangement. Telling the story of the oldest house in Washington state, and the Spokane Indians who lived here. edit
- Spokane Plains Battlefield Monument, Four Lakes, WA (at the north end of Electric Ave., just south of the freeway.). Marks the site of a battle on Sept 1, 1858 where the US military decisively defeated a confederation of the Spokanes, Couer d’Alenes, Yakamas, Palouses, and other tribes. edit
- Steptoe Battlefield, Rosalia, WA (From Seventh St., turn right onto Josephine Avenue, then turn right onto Summit Avenue to the park entrance.), . summer: 06:30h - dusk, winter: 08:00 - dusk. A small 4-acre site with a monolith, marking where on May 17, 1858 a small US Army detachment was defeated by a larger force of Spokane, Palouse and Coeur D'Alene Native Americans. edit
- Asotin County Museum, 215 Filmore Street, Asotin, ☎ +1-509-243-4659, . Exhibits about the county's history, including examples of various kinds of buildings, such as a schoolhouse and Nez Perce tepee. edit
- Walla Walla Often thought of as part of the Palouse region. However, the western boundry of the county is on the Coulmbia River.
- Whitman Mission National Historic Site, (7 miles west of Walla Walla off of Highway 12), ☎ +1-509-522-6357, . 08-18h summers, 08-16:30h other seasons, every day except three holidays. The 1847 Whitman "Massacre" horrified Americans and impacted the lives of the peoples of the Columbia Plateau for decades afterwards. $3/person, $5/family. edit