The Ohio Valley region is in West Virginia.
Sisterville to Fly. About $3.00 per car. They handle 150-200 cars per day.
One of the more scenic paths in the Ohio Valley is to drive along the Ohio River on WV Route 2, that extends from Huntington WV north to East Liverpool Ohio. Most of the road is 2 lane following the river. If you are driving a large motor home, you may want to consider a four lane road.
There are some spectacular homes on both sides of the Ohio River, both new and restored. You can exit Route 7 in Ohio and Route 2 in WV to roads closer to the River.