As prefecture, it is one of the livelier and younger towns of the Saône-et-Loire department. It's close enough to Lyon to benefit from its cultural influence but far enough away to have its own style.
Built on the banks of the Saône, what is usually reffered to as Mâcon is actually an urban area including the towns of Mâcon, Charnay-lès-Mâcon, Saint-Laurent-sur-Saône, Sancé, and many smaller villages.
At the border of three distinct regions: Burgundy, Bresse and Lyonnais, tourists can experience a large choice of some of France's finest cuisine, wines and cheeses.
You can get to Mâcon from anywhere in France by car. Paris and Marseille are both about 4 hours away, Dijon and Lyon about an hour.
As a traveler you'll either be coming from: -The north, autoroute A6: Paris or Dijon, take exit number 28 "Mâcon Nord". -The south, autoroute A6: Lyon or Marseille, take exit number 29 "Mâcon sud". -The east, autoroute A40 and A406: Geneva or Bourg-en-Bresse, you can go to either exit 1 "Mâcon nord" or exit 13 "Mâcon sud".
There are two train stations: -Mâcon Loché TGV: about 10 km outside of town. This is the station to get off (or on) a TGV from (or to) Marseille, Lyon and Paris. -Mâcon ville: in center of town for local trains, to Lyon, Dijon, and Bourg-en-Bresse. The "E" bus line goes from Mâcon ville to Mâcon Loché TGV, along with some other stops in between.
Mâcon is a small town, so you can and should walk as much as you can.
There are also a couple of bus lines, for those that don't want to walk: 
For cars, traffic is only a problem at rush hour and on Saturdays, and nothing compared to Paris or Lyon. Parking in town can be a problem as almost all lots are metered and often full.
Musée des ursulines.
Pont Saint Laurent.
Churches: -Eglise Saint-Pierre -Le vieux Saint-Antoine -Cathédrale Saint-Antoine -Eglise Saint-Clément
Maison de bois
Drive outside of town and visit one of the many wineries that make burgundy wine or drive about 20 min south and visit the beaujolais wineries which make much more (and much better) wines than just beaujolais nouveau.
In the pedestrian area, downtown there are many shops, mostly clothing, but also toys, food, home decor, etc.
You can pretty much find pretty anything you want despite the town small size: classic french cuisine (at any price range), Chinese or Indian, fastfood or daylong meals.
Any of the numerous kebab places serving up gyros and various other sandwiches for around 5€.
Choose from any of the bars on the quais (along the river) as they are almost the same: medium prices, hip atmosphere, and the main road only a couple feet away.
For something different, try the Traboule(back in an alley on the pedestrian street), somewhat like a british pub. Nice selection of beers on tap and a grungy atmosphere to go with them.
You can also try the Maison de Bois, a café/restaurant in an old wooden building on the pedestrian street.
In the summer go for the little hut like bar on the paved "Esplande Lamartine" along the river, no table service and plastic cups, but one of the cheapest in town and nothing beats sipping a nice drink on a chaise longue in the summer heat as the river slowly moves along.
Of course you can also head out of town during the day and hit up one of the many local wine producers for some white or red burgundy or beaujolais.
There are a couple of hotels in town, or you can try futher out for cheap lodgings like Formula One.
Chateau de Pierreclos
Parc des oiseux