California State Route 198 passes through Hanford allowing access Interstate 5 to the west and California State Route 99 to the east.
Amtrak's San Joaquin route stops at the Hanford station. The station is located at 200 Santa Fe Avenue and includes an indoor waiting area, ticket office, and restrooms. Baggage assistance is available during station hours. Amtrak Thruway Buses connect Hanford to the Central Coast at San Luis Obispo and overnight Amtrak Thruway buses connect with the Amtrak Union Station in downtown Los Angeles.