Eastern Slovakia is bounded by Poland to the north, Ukraine to the east, and Hungary to the south.
- Bardejov — centre of the Northern Saris region, well preserved town centre is in the UNESCO World Heritage List.
- Košice — metropolis of Eastern Slovakia, second biggest city of the country with the easternmost situated Gothic cathedral in Europe, the oldest European coat of arms, a great historical city centre with the Cathedral Complex, numerous churches, palaces and interesting museums.
- Kráľovský Chlmec (Királyhelmec) – the heart of Bodrogköz (Medzibodrožie).
- Levoca — magnificent medieval pearl of the Spis region surrounded by town walls with a unique renaissance town hall, burger's houses, numerous churches and St. James Cathedral where the biggest Gothic wooden altar of the world is situated.
- Poprad — gateway to the Tatras National Park
- Prešov — the best example of renaissance architecture in Slovakia, numerous churches and nearby lying Solivar which is one of the most interesting salt mine museum in Europe.
- Vysne Ruzbachy and Bardejovske Kupele — Well-known Slovakian spas
- Ždiar - highland village in the Tatra Mountains with original folk traditions and ethnographic museum.