Cairo is in Illinois, USA on small strip of land in between Missouri and Kentucky as well as the confluence of the Ohio and Mississippi Rivers, made famous in Mark Twain's "Huckleberry Finn".
- US 51. Head south on US Highway 51 from Interstate 57.
- Cairo Regional Airport, CIR. Located 4 miles northwest of town on the other side of the interstate.
- Cairo Custom House Museum, 14th and Washington Ave, +1 618 734-9632. An American Civil War and local history museum. M-F 10AM-12PM, 1PM-3PM.
- Fort Defiance State Park. This once neglected state park has come back into better days thanks to local efforts. It looks out over the Ohio and Mississippi rivers as the two powerful water flows attempt to combine.
- Safford Memorial Library, 1609 Washington Ave, +1 618 734-1840. Home to Civil War documents, antiques, and paintings. M-F 10AM-5PM, Sa 9AM-12PM.
- Levee Footrace, +1 618 734-4400. A 5000 and 10,000 meter run held on the Mississippi River Levee is held the second Saturday of November.
- St Mary's Park. This city park once played host to Theodore Roosevelt, but now hosts the city's residents with recreation facilities.
- Lokafy, connects travellers with locals and ensures a full experience.
- Andy's Drive-In, +1 618 734-4361.
- Cairo Truck Stop, +1 618 734-9161.
- Chris's Cafe, +1 618 734-9880.
- Dairy Hut, +1 618 734-1266.
- Mack's Barbecue, +1 618 734-9847.
- Nonny's, 2203 Sycamore, +1 618 734-1883.
- Nu Diner, 300 Washington Ave, +1 618 734-2373.
- Belvedere Motel, 3901 Sycamore St, +1 618 734-4020.
- Days Inn, I-57 and US 51, +1 618 734-0215.
- Garden Inn Motel, US 51, +1 618 734-9554.
- Relax Inn, 214 Washington Ave, +1 618 734-0285.