By bus or by taxi
you can use egged buses from Tel Aviv (842, 841), Haifa (301), Jerusalem (962, 963) and Tiberias (835, 841, 962, 830). From other cities in the the valley (Migdal Ha'emek, Bet Shean, Nazareth) you can get to Afula by Kavim buses  or by sherut (shared) taxis. Sherut taxis also available from Tel-Aviv, Haifa and Tiberias. Note that buses departing from Afula to bigger cities stops at 22:00.
Givaat Ha'more - "the hill of the instructor" - one of the mountains surrounding Jezreel Valley. Nice place for easy hike. It's highly recommended to go all the way up to the mountain viewpoint in order to watch the beautiful landscape from above.You can go up with Kavim buses from Afula (Lines 3, 14, 2 bus ticket costs ₪6.70 and you can use the same ticket all day long).
Daily tours - You can go out of Afula for daily tours in Tel Meggido (archeological site. 10 minutes drive), Mount Tabor (Holy place for Christians. 10 minutes drive) and many others.
G - BA'EMEK (AKA Ha'Mitham) - is a large shopping center located near the road from down town Afula to Givaat Ha'more. To get there you can use all of the buses from Afula to Givaat Ha'more or to Afula Elite (Upper Afula) - 10, 3, 2, 9, 14 and 13 (Bus ticket costs ₪3.80 or ₪5.80 for all day). In this large and modern shopping center you will find Cafes, restaurants, clothing shops and many other shops.
Falafel Golani - Locals say this is the best falafel in the middle east. Located in the center of the city, in Ha'Nasi St. (opposite to the police station). Near Falafel Golani you will be able to find many other falafel and kebab shops such as Falafel Ha'Nasi, Baguette Nir and Shawuarma Al'Fasi as well as few bakeries and pizzerias.
Spoons - coffee shop. Located in the center of the city, Near Karmel Hotel. 
HaTzarfatia HaKtana (The Little Frenchwoman) - a caf'e and restaurant in Afula, open since 1991. HaTzarfatia HaKtana has been managed for the last 12 years by Tami and Dganit, who have turned it into a well known spot in the Afula area. This is a place to celebrate birthdays, weddings, other specials events, and of course, a place to come spoil yourself any day of the week. address: 5 Shprintsak St, Afula. Phone: +972-4-6526516 
Malon Karmel (Karmel Hotel) - located in the center of the city. Phone: +972 -4- 6522106. address: 7 Zalman Hoz st, Afula.
Ha'emek medical center - one of the biggest and advanced hospitals in the country is located in Afula, on the main road to Givaat Ha'More and Tiberias (5 minutes drive from the center of the city).