Varela is a city in Guinea-Bissau.
There is public transport from São Domingos, but if you're a group of 4-6 persons, it will be more comfortable to rent a seven-seat peugeot with a driver for some days. The trip São Domingos-Varela is some 50 km on a very bad road with many potholes. The trip will take at least two hours.
Chill out on the best beaches of mainland Guinea-Bissau
Chez Helene - hotel owned by a friendly italian, with a nice athmosphere and very yummy italian food.