Trapani is the port for frequent boats and hydrofoils to Egadi Islands. Nightly boats (and hydrofoils in summer) also run to Pantelleria, with weekly (or so) ones to Tunis. See SIREMAR  and Ustica Lines 
Trapani has a small airport (TPS). The airport is served by Ryanair, Meridiana and Air One. Meridiana fly to the island of Pantelleria, Air One (Lufthansa) to Rome. Ryanair operate low cost routes direct to Trapani from Malta, Italy, France, Brussels, Holland, Germany, Austria, Poland, the UK, Ireland, Spain, Denmark, Norway, Slovakia and Sweden. Four Ryanair B737-800s are based in Trapani, meaning delays are shorter than average due to aircraft being based on site.
As of May 2010 the following routes were served by Ryanair. Trapani [TPS] to/from:
Bari [BRI] - Bologna [BLQ] - Brindisi [BDS] - Cagliari [CAG] - Genova [GOA] - Milan (Bergamo) [BGY] - Pisa [PSA] - Rome (Ciampino) [CIA] - Turin [TRN] - Trieste [TRS] - Venice (Treviso) [TSF] - Paris (Beauvais) [BVA] - Brussels (Charleroi) [CRL] - Eindhoven [EIN] - Maastricht [MST] - Luqa [MLA] - Bremen (Summer) [BRE] - Düsseldorf (Weeze) [NRN] - Frankfurt-Hahn [HHN] - Karlsruhe-Baden [FKB] - Memmingen (Munich West) [FMM] - Bratislava (Vienna) [BTS] - Krakow [KRK] London Stansted [STN] - London Luton [LTN] - Liverpool [LPL] - Dublin [DUB] - Girona (Barcelona) [GRO] - Ibiza [IBZ] - Madrid [MAD] - Valencia [VLC] - Billund [BLL] - Sandefjord (Oslo/Torp) [TRF] - Gothenburg City [GSE] - Stockholm [NYO]
TPS airport is about 15km from the center of Trapani. There's a local bus ('AST') that costs about EUR2, leaves every 45 minutes and takes about 40 minutes .
Trapani is small enough to walk around. Buses pass the ferry port and the adjacent bus station and railway station are on the edge of the city centre.
The magnificent Basilica-Sanctuary of Maria Santissima Annunziata (also called Madonna di Tràpani) originally built in 1315-1332 and rebuilt in 1760. It houses a marble statue of the Madonna of Tràpani, which might be the work of Nino Pisano
The Baroque Palazzo della Giudecca 'or Casa Ciambra
The Fontana del Tritone (Triton's Fountain)
The Baroque Palazzo della Giudecca or Casa Ciambra
The Cathedral (1635)
The fine buildings on the main Corso Vittorio Emanuele
Enjoy the bustle of the port. See the Italians shouting and gesticulating as they load the large ferries to Tunis
The city is renowned for its Easter procession, I Misteri, when the town's guilds parade a groups of sculpted 17th century and 18th century religious statues through the streets in a procession lasting for 16 hours on Good Friday and Holy Saturday.
Scuola Virgilio, Via Garibaldi, 91100 Trapani, . Italian Language School: year-round Italian language classes, summer intensive group courses, Italian/Sicilian cookery lessons, excursions.
Calvino, Via N.Nasi, +39 0923 21464. Excellent pizza - you'll have to come early or book ahead if you want to eat in. The locals flock here for take-aways.
Da Salvator Via N.Nasi. Fairly good, cheap food.
"Trattoria Ai Solito Posto" Via Orlandini 30, A fantastic Trattoria serving traditional Trapanese cuisine. Comes highly recommended in the Slow Food guide to Italy. The spaghetti with sea urchins (ricci) and timballo of sardines are incredible. http://www.trattoria-alsolitoposto.com/chisiamo.html
Maccotta, Via del Argentieri (+39) 0923 23348. Attractive, clean and surprisingly cheap.
Camere Enny Guest House Alcamo – Contrada San Gaetano, 16, Exit Alcamo Est - 91011 Alcamo (Trapani) Italy . Telephone +39 0924 501983 • Fax +39 0924 1916046. The Camere Enny is a Sicilian guest house located in the town of Alcamo, in the province of Trapani, on the Bay of Castellamare, 44 miles away from Palermo. The 13 bedrooms of the Camere Enny can host up to five people. Available the private bath with the Hydro massage shower; plus the restaurant, wi-fi connection and private parking. Double Euros 79. Single 39.
Crystal Hotel,  Piazza Umberto I, 91100, Tel. + 39 0923 20000, Fax: + 39 0923 25555. The hotel is a modern design and is in the city centre, next to the central station on the main road.
Appartamenti Torri sul Mare, Via Silva, 3, ☎ +3909231941513, . From €20 per person.
casaKalos, Largo San Domenico, 8 (91100 Trapani), . Superb brand new apartments in the heart of Trapani historical town. Sandy beach 150m. Ideal for relaxing beach holiday and a perfect headquarter for excursions in the wonderful surroundings.
Case Colomba, 183 Toselli street (trapani), ☎ +390923852729, . Case Colomba - Buseto Palizzolo The house, which dates from the end of the nineteenth, is a old rustic style situated near Trapani.The geographical location makes it an ideal starting point for daytrips to numerous places. Italy Ecolabel Award 2006 for environment.35-50.
Relais Angimbé Segesta – Viale le Colombo, 175 - Cap: 91013, Calatafimi-Segesta (TP), Italy. . Telephone +39 0924 530120 • Fax +39 0924 530112. The Relais Angimbé is an elegant and relaxing four star hotel located on northern coast of Sicily, 41 km away from Trapani and 76 from Palermo, with its own restaurant and wine tavern, and 15 bedrooms and suites. Also available a large conference centre. Double standard 89 euros, Superior 109.
Villa Anna, 250m from the sea, Marausa Lido (Trapani 9km, Trapani Airport 5km), ☎ +44 7980 575998, . A delightful privately owned 4 bedroom villa within 250m of the sandy beaches in quiet Marausa Lido, just 9km from the centre of Trapani, sleeps 2 - 10 people. Restaurants and bars within easy walking distance of the house.From €14 pppn.
I Colori del Vento B&B, Viale Regina Elena 62 (Trapani - centre), ☎ +39 347 250 46 30, . checkin: 24 hours; checkout: 10.00 A.M. Romantic B&B with an amazing seaview in the historic centre of Trapani.
Novecento B&B, Via Conte A. Pepoli, 80, ☎ (+39)3406264834, . checkin: 8:30am - 1:25pm and 8:00pm - 12:25am; checkout: 10:00am. True B&B: the owner lives in the house and a full vegetarian breakfast is served on our terrace - Free bicycles - Free H24 internet access. In Trapani, the Western point of Sicily lays an oasis of sustainable tourism.from € 15,00 p.p..
Erice is well worth a visit. Regular buses go to this nearby precipitous hilltop town, but the best way to get there is by the new cable-car. Wander around and soak in the atmosphere.
The Egadi islands (Favignana, Levanzo e Marettimo) are very close and well worth a visit, with their wonderful beaches and bays.
San Vito Lo Capo is a wonderful beach 40 km from Trapani, with white sand and crystal blue sea.
Visit the Greek temple, theater, and ruins at Segesta on a day trip, or en-route to Palermo.
The beaches of Scopello are not to be missed (featured at the end of the movie Ocean's Twelve).
The long sandy beaches of Trapani and lido di Marausa are within 1k and 10km of the town. There is a salt museum in Nubia on the way to Marausa, detailing the history of the salt pans in the area, and Trapani's important position on the 'Salt Road'.