Santarém is located on the southern bank of the Tapajós River (a tributary of the Amazon), in northern Brazil. It's the second-largest city in Pará, and located just about midway between Manaus and Belém.
Santarém is about 36 hours by river boat from Manaus and a couple of days from Belem, making it an ideal place for a few days' stopover on a trip along the Amazon. Boats leave Manaus every day besides Sunday. There are usually 3 boats leaving from Manaus, however on Wednesdays only one boat leaves and costs R10 more than usual for first class. Usual cost is about R110-120 for first class (top deck with a hammock.)
History Museum João Fona , on the eastern end of the waterfront. Good for a half-hour's worth of learning about the city, and attended by a helpful staff. Between the millennia-old pottery shards and the portraits of every single mayor of Santarem, there should be something to hold your attention.
Museum do Índio; Museum de Arte Sacra; Museum Dica Frazão.
Santarém has two ports: Docas do Pará serves farther destination like Manaus and Belém while a smaller port near Praça Tiradentes serves destinations on the Tapajós river and other local destinations like Monte Alegre and Alenquer.
Alenquer is a small town on the north bank of the river. From there, it's about two hours by taxi to Vale do Paraíso, an eco-resort built around the Viuva da Noiva waterfalls.