By car, Portsmouth can be accessed using U.S. Route 23 (North/South) and U.S. Route 52 (East/West). Greyhound serves Portsmouth as well. By boat, Portsmouth can be accessed by using the Ohio River. By Canoe, Portsmouth can be accessed using the Scioto River. By Plane, Portsmouth can be accessed through the Portsmouth Regional Airport located in nearby Minford.
Other than a couple cab companies, there are no forms of public transit. Although, a traveler can easily walk to many locations downtown.
Portsmouth is full of history so take time to visit the antique shops, cafes and pubs in the Bonneyfiddle District. One of the main attractions in Portsmouth is the 2,200 foot floodwall mural painted by famed artist Robert Dafford. It is truly amazing and quite unique.
Shawnee State University - one of Ohio's fastest growing universities.
Southern Ohio Museum, 825 Gallia St., 1+ 740-354-5629 
The World Championship of Cornhole takes place each summer in the nearby Village of South Webster. Teams from around the state and country visit the area on this weekend to take place in this popular sport. Also held each year is the Southern Ohio Machine Gun Shoot in Minford. Owners of machineguns and spectators gather in June to fire these historic and exotic weapons.
Ports City Cafe & Pub
Ye Olde Lantern
Jade East, 3556 Rhodes Ave, ☎ (740) 456-8078. 1100-2200. Excellent Chinese-American cuisine. All food is created by the chefs, egg rolls are hand rolled, soups are created from scratch. Always a good choice
The Ports City Cafe & Pub
Ye Olde Lantern
Frank & Steins
Party Time Pub
Clock Bar & Grill
The Ramada Inn is located right downtown near the river. Other chain hotels are located in the north side of the city and in nearby Wheelersburg, east of Portsmouth.
Holiday Inn Express, 5100 Old Scioto Trail, +1 740 353-3232, .
Shawnee Resort & Conference Center,  4404 State Route 125, Portsmouth. Located in the 63,000-acre Shawnee forest, the Shawnee Resort & Conference Center offers a many vacation attractions and amenities, golfing along Ohio River, indoor or outdoor pool. 65 miles of adjacent hiking trails, ideal for avid hikers or photographers. A cedar and flagstone lodge with 50 rooms, 25 2 bedroom cottages, and the O-Hee-Yuh Restaurant.