Phoenix to Las Vegas by car
It's only 300 miles from Phoenix to Vegas, and the distance between the two along the shortest line could easily be covered in a day. However, the number of sights and the sheer variety of scenery along and around this route is simply staggering, and a leisurely drive gives an excellent introduction to America's Southwest.
Both Phoenix and Las Vegas are major transport hubs accessible by plane from all over the United States. Cars can easily be rented at either, and you can usually negotiate a free drop-off at the other end.
Day 1: Phoenix to Flagstaff
Flagstaff has a better range of accommodation and nightlife, but if you want to drive a little more today and a little less tomorrow, consider continuing on to Sunset Crater and Wupatki and overnighting at Cameron or Tuba City instead.
Day 2: Flagstaff to the Grand Canyon via Monument Valley
Day 3: Grand Canyon
Day 4: Grand Canyon to Las Vegas
Much of the route is in desert areas where summer heat can be fearsome and gas stations are few and far between. Take plenty of water, and fill up your tank before heading off the Interstates.