South Philadelphia district, highlighted on map of Philadelphia County. Click for larger image
Famous for its Italian heritage as well as being featured in Rocky, South Philly is also home to FDR Park and all of Philadelphia's major professional sports teams (at least until 2010, when the city's MLS team, Philadelphia Union, begins play in the suburb of Chester). You want a cheese steak? South Philly's where it's at! Recently, South Philly has become home to many Asian and Mexican immigrants. It also includes Ninth St Market (aka Italian Market) and East Passyunk St (roughly 11th and Passyunk SE to Broad St and Snyder), also known as Passyunk Square which is lined with shops, bars, and restaurants. Its upper boundary is South Street, arguably the center of nightlife and urban activity in Philadelphia, South Street encompasses almost every kind of urban attitude you'd expect in a major city. Tattoo parlors, cheese steak joints, local designer clothing stores, restaurants, music venues, and local cafes line South Street from Penn's Landing up to about 10th street. Every night it seems as if there is a street festival going on here.
Society Hill-Queen Village is one of Philadelphia's oldest neighborhoods, site of Gloria Dei (Old Swede's) Church. Walking around Queen Village will give you a taste of what Ben Franklin might have experienced in Philly when he was alive, as well as give you a peek at Philly's old European roots.
Society Hill A posh residential area south of Old City. Other than the stately row-houses and gleaming condominiums, there are some quality drinking and dining establishments, two of the artsy Ritz movie theaters, and a seasonally open market.
South Philly is technically considered to begin at South Street and below. SEPTA has many bus routes and subway stops to connect you to where you need to go.
The Italian Market, heading south from 9th and Christian, is always worth a visit. Like an old European market, the sidewalks are lined with stands selling cheap produce, hundred-year-old butcher shops, spice shops and Italian and Mexican delis. Get a roast pork sandwich with broccoli rabe.
Bella Vista, a traditionally Italian neighborhood just south of Washington Square, is home to the famous Italian Market, as well as an increasing number of restaurants of various ethnicities. Currently more and more people in their 20's and 30's are moving into this neighborhood, and it is becoming an increasingly popular destination for shopping, food, and drink, all within easy walking distance of South Street.
South West Center City This new vibrant area of the city extends south of South St. and west of Broad St. to the Schuykill River. Much of the movie "The Sixth Sense" was filmed in this location.
Queen Village Another vibrant area extending roughly from Lombard St. to Washington Ave. between Sixth Street and the Delaware river. It was named after Sweden's Queen Christina
Citizens Bank Field Home to the Philadelphia Phillies 
Wachovia Center Current home of the Philadelphia 76ers (NBA) and the Philadelphia Flyers (NHL). Also host to numerous concerts and other events throughout the year. 
Franklin D. Roosevelt Park. Located at the bottom of South Philadelphia and rather off-the-beaten-track for visitors (for now), this large park somewhat resembles the Tidal Basin in Washington D.C. (although less monumental for sure). It is hoped that in the coming decade, the newly re-developing Naval Business Center will become a major new business, residential, and tourist hub, which will perhaps draw more visitors to this hidden treasure. Spend a lazy afternoon stroll and watch a nice sunset in the Jeffersonian'esque marble gazeebo. Also features a good skate park. The American Swedish Historical museum, founded in 1938, is also in the park.
Navy Yard Business Center Newly re-developed business park formed from the old Philadelphia Navy Yard.
If you are a bicycling fan, can bike along the Schuylkill River from Valley Forge all the way into South Philly. A riverside park, including a multi-use trail, extends down to South St. It is hoped that further biking improvements will be made, allowing easy access across town, as 22nd St. and Washington Ave. already have bike paths.
Bicycle Therapy 2211 South St. Considered THE place to go for everything on 2 wheels. 
Fabric Row(4th Street from Bainbridge to Catharine) popular with locals and visitors seeking unique fabrics.
Mia's Boutique (1748 E. Passyunk Ave) Voted coutless time for the city's best selection of evening wear.
Claudio's Specialty Foods, 924-26 South 9th St, ☎ (215) 627-1873, . 9AM-5:30PM. This is actually two storefronts. One is a specialty foods shop with Italian and some Spanish goods but the second, smaller storefront is a "mozzarella factory." they produce mozzarella daily and is among the best mozzarellas in the US. For foodies, it's a must stop, especially if you're already at the Ninth Street Market.
South Philly has quite a few Italian restaurants plus diners and many places to eat.
The block of South St. between Front St. and 6th St houses several good eateries worth checking out.
Chickie's (10th & Federal Sts.)
Dmitri's (4th & Catherine Sts.)
John's Roast Pork (Snyder & Weccacoe Sts)
Penrose Diner (20th & Penrose Ave.)
Tony Luke's (Front& Oregon)
Champps Restaurant (Snyder and Delaware Aves) (American Cuisine)
Johnny Chang's Asian Restaurant (2601 S. Broad St.) (Asian Cuisine)
L'Angolo Ristorante (1415 W. Porter St.) (Italian Cuisine)
Mamma Maria, 1637 E Passyunk Ave. Fantastico. Just like sitting down at a table in the owners town of Valle San Giovanni in Abruzzo, Italy.
Marra's, ☎ +1 215 463-9249, . A cozy, family-owned Italian restaurant featuring award-winning pizza. 1734 E. Passyunk Ave. in the heart of South Philly's Italian district.
Popi's Italian Restataurant (3120 S. 20th St.) (Italian Cuisine)
Benny the Bum's (7th & Packer Ave.)Great bar atmosphere with a diverse crowd.
Chickie's and Pete's Cafe (1526 E. Packer Ave) A great place for every event. Huge T.V.'s are always showing games around the country, but you can also get the privacy of a booth. If you feel like picking on the food there you can't go worng with their world famous crab fries.
Doc's Union Pub (2nd & Mifflin Sts.) A classic Irish pub with classic Irish characters.
Royal Tavern, 937 E. Passyunk Avenue, ☎ 215-389-6694, . Tavern with upscale (but reasonabley priced) bar food. Plenty of vegetarian options. Popular with hipsters.
Hyatt Regency Hotel (135 S. Penns' Landing)
Renaissance Hotel '(Philadelphia International Airport)
Sheraton Suites (Philadelphia International Airport)
Holiday Inn Stadium – Philadelphia, 900 Packer Avenue, Philadelphia, PA 19148, ☎ 1-215-755-9500, . Stay at the Holiday Inn Stadium hotel in Philadelphia offering comfortable accommodations, free airport shuttle service, an outdoor swimming pool, and a convenient location near Philadelphia International Airport in Pennsylvania.