You could take a flight from Dushanbe to Khorog. There is a 14 seater flight every morning to Khorog but its departure depends on weather conditions and the number of passengers. Tickets to the flight are sold a day in advance at the Dushanbe airport.
You could share/ hire a jeep from the jeep stand near the airport in Dushanbe to Khorog. This will take between 13 and 21 hours and private hire of a jeep costs around $400.
Same as getting in.
Rice, eggs, snacks, yak butter, bread, mutton, Pamiri tea (seer-chai), freshly made warm bread (non).
Tea, surprisingly good coffee, and vodka. Yak milk.
There are a number of homestays in most villages on the Pamir highway. They are usually in homes built in traditional Pamiri style. They are made with wood, with five pillars, a sky light and richly decorated with carpets. You are ensured great hospitality and simple but delicious meals.
Khorog - Pamiri Lodge. $6 per person per night incl breakfast.
Khorog - Hotel Serena Inn. This is a more up-class hotel built by the Aga Khan Foundation in-order to encourage tourism in the region. Built in typical Badakshani style and situated right next to the river, it is very luxurious. £160 per room per night incl breakfast.
Zong Village - Homestay of Mavluda. $12 per person per night incl dinner and breakfast.
Murghab - Homestay of Talay. £12 per person per night incl dinner and breakfast.
A zealous policeman in Murgab may want to register you with the police or complain if you were taking photos. This isn't a problem, registration should be known well enough simply getting to the area.
There is some risk of altitude sickness.