Orenburg Oblast is a big agricultural producer in Russia and is not a major tourist destination. The Ural River, considered the boundary between Europe and Asia, cuts through its territory.
See Russian phrasebook.
There are two trains from Moscow to Orenburg. One of them departs every odd day around 19:00 and takes 26 hours. And the second one departs every day per week around 15:00 and takes 30 hours.
There is one train goes every day from and to Samara.