You can take a bus from Pathein or Yangon. The roads are not that good, so for the about 210 km from Yangon it will take about 6 hours, depending what bus you take. You can also go by boat from Yangon to Pathein.
You may rent a bicycle or take the bicycle taxis. Renting motorbikes is not a good idea, otherwise the unspoilt place will soon become like an overcrowded Thai beach resort.
The endless and quiet white sand beach, the lover's island, there is an 'elephant camp' in between Ngwe Saung and Pathein.