This district, comprising of the suburbs of Chembur, Mankhurd, Govandi and Trombay were considered the poorer cousins of the Western and Central Suburbs for various reasons. The rail connectivity was poor. Chembur is home to a chemical factory RCF which used to be (but no longer is) famous for its pollution. But this reputation has been undergoing a change in the past few years. Bombay has expanded into Navi Mumbai ("New Bombay") and the Harbour Suburbs are on the way. Road connectivity has improved quite a bit.
This area is also home to many educational institutes, including the Tata Institute of Social Sciences and many private colleges of engineering. The Bhabha Atomic Research Centre (BARC) is located in Trombay.
Three stations of the Harbour line of Bombay's suburban rail network serve this area - Chembur, Mankhurd and Govandi. Arriving from South Mumbai, the best place to catch the train is at Bombay CST, which is the starting point for Harbour (as well as Central) lines. For virtually anywhere else on the Central line, Kurla is the interchange point. The harbour line goes all the way up to Navi Mumbai, so if you are arriving from there, catching a train from Vashi or any other station on that line will also work.
The Eastern Express Highway has many exits that you can take to reach this area.