Mayagüez is served by PR-2, a primary four-lane road that links San Juan and Ponce and passes through most towns in the northern, western, and southwestern coasts of Puerto Rico. Should you drive it from the north, you'll enter the municipality through the bridge over the Río Grande de Añasco; from the south, you will enter town by driving past the Mayagüez Mall, right after the overpass that serves as the terminus to road PR-100, which leads to the resort town of Cabo Rojo.
Mayaguez also has a local airport, which has daily flights to and from San Juan operated by Cape Air.
Mayagüez is a small city, roughly shaped like a crescent. Many of its landmarks are within walking distance, but the location of some will demand that you use alternate means of transport. The downtown section roughly follows a grid pattern. The main thoroughfares of the grid are the Calle de La Candelaria (from west to east) and Calle Méndez Vigo (from east to west), which run parallel to each other. They are closest to each other at the town square, the Plaza de Colón (Christopher Columbus Square), whose four corners are still called Las Cuatro Esquinas by some older mayagüezanos. City Hall (whose bell tower is roughly modeled after New York's) and the local Roman Catholic cathedral, Nuestra Señora de la Candelaria are located at opposite sides of the square. Slighly west of the city center the Avenida Ramón Emeterio Betances runs across the city from north to south.
Public transportation is scarce. If you rent an automobile, be advised: parking is even more scarce. Parking meters abound in the downtown section, but parking laws are not consistently enforced. You are advised to cover your stay by using them, though; fines cost $25-$250 depending on the infraction. There are private parking lots around town, whose hourly rates are relatively cheap (roughly $1/hr), but most are small, and many close by 5:00 PM. Should you be staying at a downtown hotel you may be entitled to use a parking space at one of these for the night.
If you need to travel reliably through town your best bet is to book a taxi, which is relatively cheap compared to San Juan's (a drive within the downtown section is approximately USD$7). There are two taxi companies: Yellow Cab (just south of the Cathedral) and White Cab (on Calle José de Diego, two streets north of the Plaza de Colón)
There's a free municipal trolley which makes a short circuit between its terminal just north of City Hall and the Palacio de Recreación y Deportes, which has a large, free parking lot. It mostly runs during work hours, 7:00 AM through 5:00 PM.
If you are adventurous, you may walk to the Terminal de Carros Públicos and take a publico (fixed-route public car). Most likely you will have to wait until the vehicle is full of passengers before the driver departs. Most routes cover nearby towns as well as Mayagüez Urbano, defined roughly as the expanse covered by Betances Avenue, and PR-2 up to the Mayagüez Mall. The rides are cheap, but please discuss your plans with the driver before boarding.
In addition United States Chain restaurants like Burger King, McDonalds, KFC, Taco Bell, Sizzler, Applebees, etc. can also be found here.