Mayagüez is served by PR-2, a primary four-lane road that links San Juan and Ponce and passes through most towns in the northern, western, and southwestern coasts of Puerto Rico. Should you drive it from the north, you'll enter the municipality through the bridge over the Río Grande de Añasco; from the south, you will enter town by driving past the Mayagüez Mall, right after the overpass that serves as the terminus to road PR-100, which leads to the resort town of Cabo Rojo.
Mayaguez also has a local airport, which has daily flights to and from San Juan operated by Cape Air.
Mayagüez is a small city, roughly shaped like a crescent. Many of its landmarks are within walking distance, but the location of some will demand that you use alternate means of transport. The downtown section roughly follows a grid pattern. The main thoroughfares of the grid are the Calle de La Candelaria (from west to east) and Calle Méndez Vigo (from east to west), which run parallel to each other. They are closest to each other at the town square, the Plaza de Colón (Christopher Columbus Square), whose four corners are still called Las Cuatro Esquinas by some older mayagüezanos. City Hall (whose bell tower is roughly modeled after New York's) and the local Roman Catholic cathedral, Nuestra Señora de la Candelaria are located at opposite sides of the square.
Slighly west of the city center the Avenida Ramón Emeterio Betances runs across the city from north to south.
Public transportation is scarce.
Mayaguez Zoo, (Take Route 108 past the University, then turn right at the sign for the zoo.). We-Su 8:30AM-4PM. The zoo contains a nice selection of animals which are divided into two groups, the African Forest and the African Savannah. The zoo was recently renovated and it is well kept. A favorite feature of the zoo is the bird sanctuary where you go into a open outside room with a netting ceiling where colorful tropical birds and parrots are free to fly and hang out with you. (Note this closes before the zoo itself.) You may see friendly iguanas walking by seeking a cool shaded spot.
University of Puerto Rico - The Mayaguez Campus is the college of Arts and Sciences. It has a renowned engineering school with companies recruiting graduates from the mainland United States.
Visit the colonial style city Hall and Cathedral.
Visit the local parks: Parque de los proceres, Parque del tercer milenio.
Visit the museums: MuSA in the University of Puerto Rico and the Eugenio Maria de Hostos Museum in Rio Cañas area of the city.
Mayaguez is similar to most U.S. cities in that you will find stores such as Sears, Wal-Mart, and KMart.
In addition United States Chain restaurants like Burger King, McDonalds, KFC, Taco Bell, Sizzler, Applebees, etc. can also be found here.
Gonzalez Sea Food, Carr 102, Km 6.6, Guanajibo, ☎ 787-265-7497.
Mia Bistro, Calle Del Rio Norte #13 (In Downtown Mayaguez, facing the Catholic Chruch, (in front of Plaza Colon) two blocks to your left.), ☎ (787) 831-6100, . 11-6. Lunch is a fusion of Puerto Rican/European cuisine, but dinner leans more toward Italian. Dinner Thursday-Saturday 6pm-10pm$8-$20.
Pizza Circo (El Circo), found in the Mayagüez Mall, ☎ 787.832.3556. Great pizza for a good price with fantastic service. There is also a good selection of sandwiches and italian food. Must try the home made Gelato as well - it's a treat.
Sancho Panza Restaurant, on the Mendez Vigo Rd. For a mix of Italian and local cuisine
Siglo XX Restaurant, on José De Diego Street. Local Puerto Rican Food
The nearby towns of Rincon, Aguada & Isabela offer beautiful beaches, surfing and accommodations. Head South to the bioluminescent by at La Parguera.