Los Mochis is a port city on the eastern coast of the Sea of Cortez. It's main interest for tourists is as a transportation hub. Los Mochis has an airport, ferry docks for transport across the Sea of Cortez to Baja California. It is best known as one of the two terminus points for the Chihuahua al Pacifico Railroad (El Chepe) --- the magnificent train ride through the rugged Copper Canyon.
Los Mochis has a small airport (IATA:LMM) serving a limited range of destinations. Most flights are on small regional jets or turboprops. Direct flights to Los Mochis are available from:
Delta has apparently stopped its flight from Los Mochis to LAX.
The Chihuahua al Pacifico Railway is one of the world's most spectacular train trips. The trip between Los Mochis and Chihuahua is about 14 hours each way. First class (express)trains leave each end point at 6am and the second class (tourist) train leaves one hour later. The first-class and second-class trains are essentially the same, except that the express stops less and is twice as expensive.
The real scenery starts at El Fuerte. Stand on the western side and travel uphill to Creel or Chihuahua. Hang out in the few open vestibules with your camera -- the uphill scenery is fairly splendid for at least two of the seven or nine or twelve hours of the journey. On the downhill run, put yourself in the club (bar) car, where you can stretch out in a modicum of comfort. Consider splitting the long train journey in half by spending a night or two in Creel, for instance.
Ferry boats run between La Paz and the Topolobampo docks. The ferry transports both passengers and vehicles, though there has been talk in recent years of restricting RVs. Since privatization fares are increasing very rapidly, about $80USD currently (salon class).