Great Northern Highway
The Great Northern Highway passes trough desert so you should take plenty of water and fuel with you on your trip. You should take food with you too, because there are not many stops on the way.
You can get onto the highway from Perth on the south end and from Whyndham on the north end
Most of the route passes trough the outback, so you should take lots of water and fuel with you, there can also be animals on the road, so do not drive at night. The Great Northern Highway is in Australia so you will be driving on the left, see Driving in Australia for more information.