The central part of the Garden Route is formed by the coastline of the Indian ocean. To the north it is bordered by the little (Klein) Karoo, a semi-desert region.
As local public transport between the towns is rare (except minibus services), the best way to tour the Route is by car.
As a main tourist destination there are many restaurant for every taste. Enjoy superb fish from the ocean and Knysna is the place to taste some oysters.
There is no shortage of all kinds of accommodation but book ahead on weekends/ holiday.
Compared with the larger cities the towns along the Garden Route are quiet safe. As always use your common senses. Driving at night is never considered safe in South Africa so plan ahead.