Most of Upstate New York and certainly the Finger Lakes Region is historically rooted in American Indian heritage. Watch for the common Indian names, like Skaneateles Skan-e-at-las which means Long Beautiful Lake in Iriquois.
Most travel in this area will be by car. Unless you are traveling on an organized trip and transportation is already arranged, you will want to drive or rent a car.
Stop in and see the National Women's Hall of Fame in Seneca Falls.
Cornell University is in Ithaca.
In the summer, the Finger Lakes are home to many great music and arts festivals, including the Finger Lakes GrassRoots Festival of Music and Dance.
Also, check out the Rochester Folk Art Guild, a local community of craftspeople who have been creating fine art for over 35 years.
Skaneateles Village is a must. It's a "cute-as-a-button" StoryBook Village perched on the edge of the lake. The Creamery local historical society can tell you all about the "teasel" and the Lightning Class Sailboat. Watch for their Wooden Boat Show, Chamber Music Festival and Charles Dickens Christmas.
Fantastic wine can be had from wineries. The Cayuga Wine Trail has a flavorful and educational tour every spring featuring herbs and food at each wine tasting stop.
If traveling in this area during the winter months, be aware that heavy snowfalls are possible. Lake effect snow has been known to drop four feet of snow in a weekend, or more. It is not unusual during heavy storms for it to come down at a rate of one inch per hour.