Turkish Airlines  offers daily domestic flights from Istanbul(IST) and Ankara to Diyarbakir (DIY).
There are trains three times a week from Istanbul (Güney Express). There is also a daily train from Ankara (4 Eylül Mavi Treni).
When traveling from Diyarbakir to west by bus be prepared for several ID check ups at military checkpoints.
The old city containing the mosque is a little run down but enclosed in some magnificent walls. It is like a village in the middle of the city with village mentality; goose running around, women having cay in front of their houses and kids shouting to foreigners the few English words they know. To avoid problems, dress modestly. There is extensive development outside including a pleasant park. It's called Gazi Köske and it contains many teahouses and traditional bed-like constructions, where you sink into cushions and drink tea while overlooking the Dicle river below.
Virgin Mary Syrian church, in the centre of the old town (signposts indicate where the church is). posted on the entrance. Free.
Ruined Armenian church, Next to the Syrian church (signposts indicate where the church is). Free.
The famous Grand Mosque (Ulu Cami).
There are many teagardens in Ofis and along the Basalt city walls, where you can meet locals. People in Diyarbakir are very open towards foreigners and you'll have a hard time paying for your own tea.
Mahya (mosque lamp of coloured glass), Dicle sokak 2a (In Ofis, just off the main street where buses run from bus station to city center). Open till late at night. This coffeehouse has over 70 varieties of coffee and a nice interior. The owners and customers are very friendly and easygoing.
There are many clean and reasonably comfortable hotels with air con, etc. There is an engaging hotel in the old han building.
One cheap option is Divan Otel at Gazi Cad. # 9.
Village home stays, Yuvacali Koyu Hilvan, ☎ 904145533842, . checkin: flexible; checkout: flexible. Offers village home stay in the huge rural area that stretches from Diyarbakir southwards to Sanliurfa. An opportunity to experience rural life in Turkey's southeast. Pick ups from central Diyarbakir or the airport at minimal prices, and free pick up from the centre of Urfa, Urfa bus station or Urfa airport. Sleep on handmade woollen matresses under the stars just as the locals do, learn how to make village bread, join in with the milking and the cheese making, enjoy food that is not only home cooked but also home grown and see how local people really live. An English speaking guide is available whenever required. A range of packages are available from accommodation only to full board and excursion packages.From 20TL.
Hotel Surkent, Hz. Suleyman Cd, number 19 (Close to the wall and center.), ☎ 0.4122281014. checkout: 11. It ıs a clean place, well located and wıth a very reasonable prıce. It ıs recommended by Lonely Planet. 25 tl sıngle room ın february 2010..
Diyarbakır is rough. At first glance, it seems not a very welcoming city, actually it is the contrary. Lıfe in this city is hard for so many people. It is not advisable at all to walk alone during the night time, especially in the old quarter. Taking some precautions during the visit is advisable, just common sense. Don't hang around in dark areas; try not to look like
the typical tourist, etc.
Karacadag, the forerunner of domesticated wheat originated in the mountains of Karacadag. Cultivation of wheat in the area dates back to approximately 8,800 BCE. Today Karacadag is home to seasonal nomads. Explore the ancient villages populated by Turkmen and Kurdish tribes.
See where the first animals in the world were domesticated as mankind started settled farming at Çayönü around 40km north-west of Diyarbakir. The site is hugely important for neolithic research and dates from 7200 to 6600 BC.