Clermont County was home to Miami, Delaware, Mingo, Ottawa and Cherokee tribes and as European and American settlers came to the Nortwest Territory the county became home to a large immigrant population, most notably German immigrants.
The county played an important role in the Underground Railroad due to its location in Southwest Ohio on the border with Kentucky. The county had several "stations" and was home to numerous high profile abolitionists including. Charles "Boss" B. Huber helped hide an estimated 300 - 500 fugitive slaves. Huber’s neighbor, Dr. L.T. Pease took over the role Williamsburg's stationmaster upon Huber's death.
Clermont County's most famous son is Ulysses S. Grant, born Hiram Ulysses Grant in Point Pleasant, a small village along the Ohio River. Grant became one of America's most important military leaders during The American Civil War. His wartime success led him to become the next American President after Andrew Johnson succeeded to the presidency after Lincoln's assassination.
U.S. Route 50 connects Annapolis, Maryland to Sacramento, Maryland via Clermont County. U.S. Route 52 follows Clermont County's southern border along the Ohio River. U.S. 52 connects Charleston, South Carolina with Portal, North Dakota.
The biggest danger in the rural areas include the possible meth labs, which are continously discovered in the rural back roads of Southwest Ohio. Milford-Miami Township is the most versified and liberal area of Clermont County. Additionally, Milford-Miami Township is among the safest places in the tri-state area.