The "Great Shellfish Bay," as it was known to Algonquins, is the largest estuary in the United States, at a full 200 miles long, and as wide as 30 miles. A good 10,000 years ago, this region was a valley lying along the Susquehanna River on its way to the Atlantic, but was flooded as the end of the last ice age led to rising oceans.
The Bay is one of the most naturally productive bodies of water in the world, in terms of aquatic life, because of its brackish salt-freshwater mix, and its shallow depth. The average depth of the bay is a mere 30 feet! These attributes combined to make the Bay an extraordinarily attractive for fishing, especially for shellfish like blue crabs, oysters, and mussels. Given the nature of the Bay, a famous Japanese fish farmer once boasted that, were the U.S. government to hand the Bay over to him, he could feed the entire world from farming just the Chesapeake alone.
Given its extraordinary productivity, the Bay has throughout its human history always been a major population center in the region. Before European settlers arrived, the shores were populated by Algonquian tribes, such as the Powhatan Confederation, Piscataway, and Nanticoke, as well as the Iroquoian Susquehannock in the north. Early British settlers gravitated towards the Bay for much the same reasons of easy fishing, and the communities surrounding the Bay such as Jamestown and St. Mary's City are some of the oldest European settlements in North America.
Today, however, the Great Shellfish Bay has been in a state of long-term decline for decades. Over fishing has been a problem, but may not have been possible if it were not for pollution. The Bay is plagued by agricultural and residential run-off of fertilizers into the Bay's tributaries, which causes enormous algae growth, which in turn chokes off the natural plant life of the bay upon which the fish rely for food. Environmental reforms have been enacted to protect the Bay (most strictly in Maryland, where the Save the Bay movement originated) but they differ state-to-state, and the tributaries of the Bay run through six states, making coordination difficult. This all has been a disaster for the fishing communities (especially the small island communities) around the Bay, who relied on hauls for almost their entire livelihood. Fishing is now tightly regulated, and the regulations have a good deal of support even from the fishermen, who realize that their way of life is threatened by the diminishing fish stocks.
Flora & fauna
If traveling from far away, the best way to get in is probably BWI Airport. It is close to the major ports of Baltimore and Annapolis. BWI Airport is served by many major airlines and passenger rail service via Amtrak.
Route 50 is the most iconic Chesapeake Bay road, as it goes over the spectacularly large Chesapeake Bay Bridge  (US Hwy 50/301), crossing from Central Maryland to the Eastern Shore; it also takes you right by Annapolis and Sandy Point State Park. On the east side of the bay, Route 301 is the main north-south road. On the northwest section above Baltimore — Route 40. In Southern Maryland, Route 4 is the most useful road, and in Virginia you can get around the southwest portion of the Bay on Route 360. The Chesapeake Bay Bridge-Tunnel  is on US Route 13, and has a hefty toll of $12 each way, or $5 return within 24 hours (higher for trailers and large commercial vehicles). The bridge connects the Norfolk-Virginia Beach area with the Eastern Shore peninsula. If coming from the northeastern states, you can access the Eastern Shore by going south on US Route 13 through Delaware with no bridge crossing (Delaware I-95 South Exit 4A). These are the only two bridges which cross Chesapeake Bay, and their web sites can easily be confused with each other for those unfamiliar with the region.
The best way to access the sights mentioned in this article is to use a boat. Getting access to a boat is sometimes a bit tricky, but here are some suggestions:
Some people prefer boats powered by the wind, others prefer those powered by motors.
If you are using the aforementioned wheeled conveyance to visit these sights, there are a fine collection of roads, but only three crossing points in the 120 mile length of the bay. This makes some itineraries inconvenient.