From Amsterdam, Breda can be reached by taking the A2 to Utrecht and then the A27. Breda is less than a 90 minute drive from the three main ferry ports in Holland. The closest port to Breda is Europoort in Rotterdam which is 45 miles away. 
You can get around by bike (rent from Central Station) or Citybus. But almost everything in the city centre is walkable.
Some of Breda's medieval buildings have been demolished in the past, but much remains. On the Grote Markt, the city's main square, you can find the Church of our Lady, in Gothic style, and the 18th century city hall.
Visit the OLV Church
Get a tour through the old moats of Breda
Drink real Belgian and Brabants beer on Grote Markt or Havermarkt square.
Explore the nightlife on thursdays, fridays and saturdays around Havermarkt square.
You should visit the Wilhelminastraat. It is located just south of the city centre and hosts lots of exlusive shops. It has a very rich and nice atmosphere
It is also recommended to visit the old neighbourhood Zandberg and Ginneken, just south of the Wilhelminastraat. It has lots of old merchants' houses and on the south end you will find the Mastbos. One of the nicest forests in the Netherlands
Breda is a well known shopping city in the Netherlands. In the old city centre you can find lots of clothing shops.