From David: there are several refurbished school buses leaving every 45 minutes until 8PM. Travel time is around 1 hour and cost is $1.45 which you pay when getting off. Look for the yellow schoolbus with the biggest line and a big "Boquete" sign painted across the front windscreen.
From San Jose in Costa Rica: there is one morning bus leaving from the Tracopa terminal at 7:30AM ($15-20). It takes about 9 hours to get to David. From David see above.
From Panama City : AirPanama  and Aeroperlas have daily flights to David. The flight takes about 50 minutes, prices range from $80.50 to $101.50 each way.
There are regular buses from the Albrook bus terminal, run by at least three companies (Panafrom, Padafront, and Terminales David); between them, there is a bus leaving about every hour. Daytime fares (as of August 2010) are $12.60; there are also nighttime express buses for $15. It is an air conditioned bus and it makes one 20-30 minute meal stop in Santiago. It takes roughly seven hours to get there.
There is a once-daily, $29 shuttle between Bocas del Toro and Boquete (as well as several daily buses between David and Bocas, which are cheaper but take slightly longer). Call or e-mail tour operators in Boquete for details.
Boquete is a very cozy mountain village so you won't have problems exploring the city on foot. For the surroundings you can either use taxi (one dollar brings you quite far) or the local area buses which leave from the central park. There are also many tour companies that offer guided trips through the mountains to see waterfalls, coffee plantations, the cloud forest, and the National Park.
For more extensive information, there is the Boquete Visitor Center located in downtown. This place offers free, up-to-date, reliable info on tours, restaurants, accommodations and transportation. Their phone number from within US is 786-207-0727, from Panama 507-720-2545.
Boquete is known as the "Valley of the Flowers". Nestled in the western highlands of Panama, near the border to Costa Rica. Boquete shares some of the same mountain ranges with Costa Rica, as well as, some of the incredible wildlife and rain forests. However, because it is not as well known, and a 'road less traveled', prices are lower, and it is not as commercial. There are hostels for $5 a night, and 5 star hotels for $300 a night. You can hike for 1/2 a day, or all day, and still have a chance to see the Resplendent Quetzal, or a Howler Monkey in the wild. The Boquete Valley is rich with agriculture as well; strawberries, oranges, and coffee come from this region. The famous 'geisha' coffee, that was sold at auction, for $130 a pound, can be found growing on the rich Volcanic slopes. Adventure travel is a key reason that Boquete, a fairly small town, is growing in popularity for European, American and Asian travelers. It is difficult to come to Boquete for just a couple of days and see all that it has to offer.
Horseback Riding in the Mountains of Boquete
Entrance Sign for the Volcan Baru National Park
Hot Springs pool in Boquete
Reach the Top of the Volcano Baru - There are two ways to reach the summit of the Volcan Baru. You can hike which will take about 12 hours round trip. Or you can catch a ride with one of the 4 x 4 jeeps servicing the park; this option still takes about 8 hours, the road is very rough. Notice: the climb is very difficult because of the length and steepness of the trail. take into cosideration!
Hike the Quetzal Trail, one of the most famous trails in all of Panama, the Quetzal Trail; so named because it is the home of the rare Resplendent Quetzal. You can hike from Boquete to Cerro Punta (mostly uphill), or the reverse (mostly downhill). It is about a 5-7 hour hike, so it can be completed in one day. Currently closed for repairs following the death of a guide.
Visit a Coffee Plantation--See what all the buzz is about regarding coffee tours in Boquete; from 2 to 4 hours: Cafe Ruiz  and Kotowa.
Whitewater River Rafting on the Chiriquí Viejo--Several companies offer 1/2 day and full day rafting excursions.
Zip Line through the Canopy of the Cloud Forest
Hot Springs Caldera -  Hot and Bubbly mineral water right next to the Caldera River! Take a dip in both hot and cold. Taxis currently charge $30 to $36 for the round-trip journey. There are also a few buses between Boquete and Caldera - from the bus stop in Caldera it's about half an hour walk to the hot springs. After the bridge over the river, the real hot springs are to the left. Don't expect too much from the hot springs themselves though, they are currently just a few warm puddles on a finca with some rocks built around them. To the right, the path leads to some "hot springs pool" built out of rocks where (most?) tourists that take a tour are taken to instead (see photo below).
Horseback Riding in The Mountains of Boquete - Add a Coffee Tasting to your Horseback Riding Excursion. The Coffee Estate is 10 minutes from the Horse Farm.
Yellow Jeep Tours crossing river on the way to the Caldera Hot Springs
Boquete Outdoor Adventures (BOA), Main Street, Boquete (Los Establos Mall), ☎ 011-507-720-2284, . 9am-5pm. Whitewater, sea kayaking, multi-sport and family adventure vacations.
Finca dos Jefes, Boquete, ☎ 6677 7748, . Visit Finca dos Jefes and experience the only hands-on roasting tour in Panama.
Boquete Rock Climbing, ☎ +50767647918. Expert rock climber Cesar takes prospective scalers to an unusual volcanic rock face just outside of town. There is one 5.6 path and several 5.9 paths. $40 for 4 hours, with harnesses and ropes provided.$40.
Boquete Mountain Safari Tours (The Famous 4 x 4 Yellow Jeeps), Los Establos Plaza (Center of Town right next to Banco General), ☎ 507-720-1147, . Ride in the yellow open air jeeps; Cloud Forest Safari's; Horseback Riding; Hiking; Caldera Hot Springs; Coffee Tastings. Also, trips up the Volcan Baru; either hiking or 4x4 driving. Shuttle service to Bocas from Boquete, or Boquete to Bocas del Toro.
Solar powered chlorine-free swimming pool, Rancho de Caldera Eco Resort Hotel (20 minutes from downtown Boquete in Caldera), . Swim in what is likely the regions - if not the country's - only solar powered chlorine-free swimming pool with a beautiful view of Boquete's green hills. Pool open to Madre Tierra restaurant guests and overnight guests at Rancho de Caldera Eco Resort Hotel.
Zanzibar. This chilled bar offers live music at weekends, and is extremely popular. *La Cabaña Late night bar, open Fridays and Saturdays only.
Madre Tierra Restaurant at Rancho de Caldera Eco-Resort, Caldera, Boquete, Panama (On site at Rancho de Caldera Eco-Resort (see separate listing)), ☎ (507) 720-4225, . Wine and beer are served, as well as delicious healthy beverages prepared with local fruits and herbs and sweetened with honey - instead of refined sugar.
Boquete Jazz&Blues Festival, Boquete/Chiriqui, ☎ +507-6519-7876, . The open-air Boquete Jazz&Blues Festival 2012 will take place on March 1-4, 2012. It will feature world-class Blues as well as Latin Jazz on the fairgrounds of the Feria de Las Flores in Boquete. Admission is $15/day or $25 for a festival pass.
There are several inexpensive hostels around and within a few blocks the central park.
Hostal Paradiso, right opposite the bus station and the central park. Bit noisy since it's right on the street, mind your belongings. I little run down, but Pancho the owner is very friendly and helpful. 8.50 US for dorm.
Nomba Hostel, (One block west and one block north of central park), ☎ 6401-6278 (6497-5672 (firstname.lastname@example.org), . Cheap, friendly micro-hostel just off the main street. Run by an extremely welcoming young couple. Poker nights, table football and comfy hammocks in the common area. They also rent a full range of outdoor equipment for local expeditions, and organise a wide range of adventure tours in the region.Dorm rooms (8 or 9 US) and single room (18 US).
Rancho de Caldera Eco-Resort Boquete Panama, Caldera (25 minutes from downtown Boquete, 40 minutes from David), ☎ Toll free from Canada and USA: (877) 810-0898 or (216) 220-0192, . checkin: 2:00; checkout: 11:00. Rancho de Caldera (http://www.ranchodecaldera.com) is a serene and gorgeous eco-resort (completely off the grid, on renewable energy year round) nestled in the mountains of Chiriqui; accommodations include large, spacious rooms, each with a glasswall overlooking the mountains to the east, A/C, iPod docking station, TV, mini-refrigerator and free Internet. Activities include horseback riding, hiking and swimming in a beautiful infinity-edge pool. Hot springs nearby. Rancho de Caldera's on-site Madre Tierra Gourmet Restaurant under the care of internationally acclaimed Chef Craig Miller is a popular new fine dining choice in western Panama. Rancho de Caldera, a leader in innovative, clean energy hospitality, has been recognized by Green Globe International, Rain Forest Alliance and Sustainable Travel International and is among the few lodges in the world that enjoy being #1 on the popularity index and a 100% recommendation rate from guests on the world's largest travel website,TripAdvisor.com
Boquete Mountain Casitas, Boquete, Chiriqui (Boquete is a 30 minute drive from David), ☎ 507-6613-1472, . checkin: 2:00; checkout: 11:00. Some of the casitas are located within walking distance to the village while others are on private estates in the mountains. Has one 2 bedroom, 2 bath in the middle of an Organic Coffee Farm.
Hostal Gaia, Boquete (On main street across from Roxane´s restaurant, next to Sugar & Spice.), ☎ 7201952, . checkin: 12:00; checkout: 12:00. Here at our hostel you will find a pleasant atmosphere, a fully equipped kitchen and a dining room, WiFi, camping area, and laundry facilities. from $10.
Boquete Paradise, ☎ 507-720-2278. Next to a roaring mountain stream and walking out with a view of the 11,500 ft. Volcan Baru right out of your front door. Each unit has a two bedrooms suite with full kitchen, that sleeps eight people. Breakfast is served in the morning$60 - $189.
Hostel Mamallena, Parque Central (Right on the Central Park, 30 metres from the bus stop), ☎ 720 1260, . This new hostel (sister to the established Mamallena in Panama City) is already extremely popular with travellers.Free breakfast, WiFi internet, lounge, patio, laundry. Also has private rooms with private bathrooms.Information and tours are available.
Panamonte Inn & Spa, Ave 11 de Abril, Boquete, ☎ +507-720-1327, . Famous for its gracious hospitality, charm and exquisite cuisine, The Panamonte is the true definition of a country inn: a warm and friendly place for travelers seeking a pleasurable ambiance and personalized attention, a home away from home. Located at the foot of Barú Volcano, the Panamonte is the perfect base for exploring the Chiriquí Highlands, and it is the only full-service lodging option in Boquete, offering a deluxe spa, fireside lounge, excursion planning, and a regionally renowned gourmet restaurant.
Valle Primavera, (8 minutes, walking, heading South from the central square), ☎ (507) 720-2881, . checkout: 11:00. Offers bed-and-breakfast style accommodations in a tranquil atmosphere. Rooms are comfortable and include private entrance, private bathrooms with hot water, and cable television. Breakfast included. Ideal for families, though it becomes noisy around 8am every morning, so do not expect to lie-in.US$38 (inc taxes) per room.
Hotel Isla Verde, Calle 5a Sure (Behind the School Josefa Vasquez), ☎ (507) 720-2533, . checkin: 1pm; checkout: 11am. Isla Verde offers six roundhouse cabins and four suites, all fully equipped, next to the river in a tropical garden with mountain views. Walking distance to town but peaceful. On-Site massage available.$ 80 - $ 100.
Momentum Panama (momentum panama), Alto Boquete (Left side of road going towards Boquete in alto b oquete), ☎ 7204385, . checkin: 10; checkout: 2. Momentum's fully-equipped cabins and B&B are set on a green plateau, perched on the edge of a valley alongside the rambling Rio Cochea. There’s plenty of room to wander for you and your family. Small groups welcome. (Maximum capacity 26). At 800 mt. (2,625 ft.), the temperature and distinct lack of humidity is always refreshing. Enjoy the peace, privacy and serenity of our unique location. Better yet, it all comes with spectacular ‘straight-on’ views of Volcan Baru, at 3,475 mt. (10,750 ft.), Panama’s highest peak.49.
Pamper yourself with a relaxing long gourmet weekend or mini-vacation in the lush green hills just 20 minutes from Boquete in the direction to David, at  Rancho de Caldera Green Globe Eco-Resort Project. Horseback riding, bird watching,hot springs nearby, gourmet food restaurant Madre Tierra, luxurious terraced suites with huge comfortable beds, kitchenettes and massage chairs, solar powered swimming pool and more.