Medellín - Considered by many as the best city in Colombia. Medellín is home to beautiful women, the famous yearly "Flower Festival" in August and the first (and still only) metro system in the country: "Metro de Medellín". Home City of Juanes, Fernando Botero and René Higuita. The metropolitan area is surrounded by many small towns which have become virtual suburbs of the city. These include Envigado, Itaguí, Sabaneta and Caldas (south); Bello, Copacabana and Girardota (north). The spread of the city east and west is limited by topography.
Jardín: A typical small town in Antioquia
Granada is a town at East of Antioquia. It's a zone of water, cool weather, but hot people. In this place you can say "Home, sweet home". It was the cradle of bishop Tiberio de J. Salazar y Herrera.
Marinilla, Rionegro, Guarne and La Ceja these are small towns east of Medellín and a popular day trip destination.
Jardín is a beautiful little town 2 hours south of Medellín, with incredible tourist attractions: a gorgeous main plaza, distinctive local architecture amd many country-side activities. Look for the locally produced rainbow trout and coffee to please your senses.
Capurganá even though outside of Antioquia it is easier to get there from Medellín by plane or by boat from Turbo. A great, quiet beach destination in the Atlantic, near Panamá.
Sleeping Giant mountain and Cauca River in Tarso, Antioquia
In Medellín you can get around by taxi bus or metro. The metro runs largely along the north-south axis of the city.
By cable car
Antioquia is mountainous hence Cable Cars have sprawled in the last 2 decades and are becoming popular for both commuting and tourist transportation. You can ride the Metrocables in Medellín which are additional lines of the Metro system  or the countryside cable-cars in many small towns in Antioquia : Jardín, Jericó, Sopetrán, San Andrés de Cuerquia, etc.
Mountains: The Andes are majestic in Antioquia
also by rental cars and trucks.
San Jeronimo, Sopetran and Santa Fe de Antioquia - Going north-west from downtown Medellín, you arrive at the longest and newest South American tunnel: 4.7 km. After you pass through that tunnel, you start descending mountains and a few minutes later, you are in San Jeronimo, Antioquia. Cruise it on motorcycle,  the fun way, don't be scared because its an awesome experience! Weather here is 25 degrees during the whole year. Very close you will find Sopetran, the Antioquias fruits lovely capital. Finally, you get to Santa Fe de Antioquia, one of the five colonial destinations in Colombia, and the way to the Caribbean. This road will take you to Turbo and to the Panama frontier line - the road is more safe now and is not frequented by guerrillas and paramilitaries anymore.