Medellín - Considered by many as the best city in Colombia. Medellín is home to beautiful women, the famous yearly "Flower Festival" in August and the first (and still only) metro system in the country: "Metro de Medellín". Home City of Juanes, Fernando Botero and René Higuita. The metropolitan area is surrounded by many small towns which have become virtual suburbs of the city. These include Envigado, Itaguí, Sabaneta and Caldas (south); Bello, Copacabana and Girardota (north). The spread of the city east and west is limited by topography.
Granada is a town at East of Antioquia. It's a zone of water, cool weather, but hot people. In this place you can say "Home, sweet home". It was the cradle of bishop Tiberio de J. Salazar y Herrera.
Marinilla, Rionegro, Guarne and La Ceja these are small towns east of Medellín and a popular day trip destination.
Jardín is a beautiful little town 2 hours south of Medellín, with incredible tourist attractions: a gorgeous main plaza, distinctive local architecture amd many country-side activities. Look for the locally produced rainbow trout and coffee to please your senses.
In Medellín you can get around by taxi bus or metro. The metro runs largely along the north-south axis of the city.
By cable car
Antioquia is mountainous hence Cable Cars have sprawled in the last 2 decades and are becoming popular for both commuting and tourist transportation. You can ride the Metrocables in Medellín -Additional lines of the Metro system-  or the countryside cable-cars in many small towns in Antioquia: Jardín , Jericó, Sopetrán, San Andrés de Cuerquia, etc.
also by rental cars and trucks.
San Jeronimo, Sopetran and Santa Fe de Antioquia - Going north-west from downtown Medellín, you arrive at the longest and newest South American tunnel: 4.7 km. After you pass through that tunnel, you start descending mountains and a few minutes later, you are in San Jeronimo, Antioquia. Cruise it on motorcycle,  the fun way, don't be scared because its an awesome experience! Weather here is 25 degrees during the whole year. Very close you will find Sopetran, the Antioquias fruits lovely capital. Finally, you get to Santa Fe de Antioquia, one of the five colonial destinations in Colombia, and the way to the Caribbean. This road will take you to Turbo and to the Panama frontier line - the road is more safe now and is not frequented by guerrillas and paramilitaries anymore.
Act as you would in any large, and potentially unsafe metropolitan area such as Chicago or Sao Paulo.
Don't buy drugs, or even ask about them.
Do not get in a taxi if there is someone other than the driver in it
Avoid downtown and Parque Berrio at night.
Avoid walking around like you're lost, as this may be noticed by the wrong sort of people; if you are lost step in to a cafe or "tienda", restaurant, ask someone there.
It's best to use ATMs located in exito, carrefour (supermarkets in the Medellín area)if you use the ones at the banks
Always be aware that you might be followed from ATMs and banks.