Only 150 people live on Anegada year-round.
In order to get to Anegada, you will have to fly to San Juan, Puerto Rico and then to Beef Island Airport on Tortola. From there you can take the ferry to Anegada which runs Monday, Wednesday and Friday at specific times, normally morning and afternoon, or you can take a chartered flight to Anegada via a number of airlines. Island Birds and Fly BVI are some of these.
Jeeps and trucks are available for rent on the island. If staying at the Anegada Reef Hotel or one of the villas on the island, you can inquire about having a rental car available for you at the airport.