There are mostly three ways to drive into Ísafjörður. The first is from the ringroad in Hrutafjörður, and goes up north on the eastern part of the peninsula through road number 61. That way gives you the oportunity to stop in Holmavik among other places on the way.
The second way to get to Ísafjörður by car is by road 60 from the ringroad, 608 over the moor of Thorskafjardarheidi and then 61 through the many fjords on the way. In the summer, that is the shortest way from Reykjavik, but it is currently not accessible during wintertime.
Thirdly, you can take the ferry Baldur from Stykkisholmur via the small towns on the western part of the peninsula. That way gives you a chance to see for example the great waterfall Dynjandi.
There are regular busses that go from June 1st to 31st August from Akureyri and Reykjavik. Information on that can be found on West Tours' homepage 
Additionally, there are two daily flights from Reykjavik with Air Iceland. The fare is relatively cheap if you just want to go from A to B.
The town is small, but the distances from the town to adjacent towns is further than walking distance. Thus, you would want to study the bus system that can take you all over, bring a bike or have a car. There is a bike rental in town for the active ones that don't want to walk around.
The Island Vigur is one of the most popular tourist destination near Ísafjörður.
West Tours, Adalstraeti 7 (The same house as the Information Centre), ☎ 456-5111, . Day tours and longer tours. Bird watching, kayaking, hiking, horseback riding, skiing, biking and more.
Sjominjasafn Vestfjarda Nedstikaupstadur. Maritime Museum. Open daily from 1st June to 15th Sept, 13h00 to 17h00. Small museum decided to the fisheries of the past. Nice restaurant, Tjoruhusid, is located next door and serves local fish.
Samkaup Grocery store in center city.
Gamla Bakariid Excellent bakery in the city center. Open everyday except Sunday.
Vid Pollinn The restaurant at Hotel Isafjordur.
Fernandos A restaurant with an italian touch.
Tjöruhúsið*  Popular fish restaurant. Everything is fresh. Located at the end of Suðertangi, phone number is 456-441. Open long hours in the summer but little during the winter.
Vínbúð, Adalstraeti 20, center city. State controlled wine/liquor store. Best to buy in Duty Free at the KEF airport, but if not, this is the only option.
Hotel Ísafjörður, Silfurtorgi 2.  Very comfortable and accommodating.
Hotel Edda, Ísafjörður, Torfnesi.  A part of a large chain of budget summer hotels in Iceland.
Gamla Guesthouse, Managata 5. +354.456.4146, +354.897.4146
Aslang Guesthouse- Gistiheimili Aslauger, Austurvegi 7 , +354.899.0742. A small guesthouse owned by Aslang