It is a one hour bus ride from the City of Loja. There are international buses from Piura (10 hours US$10) on Peru´s Panamerican Highway 3 times daily. Transportes Loja has buses from Loja throughout Ecuador. Access is also possible from Iquitos & Chachapoyas in Peru via the frontier at Balsas & Zumba
Self-guided treks or hire a guide into the surrounding mountains or the national park Podocarpus. Many hotels (including Cabanas Rio Yambala, Rendez-Vous, Rumi Wilco, and Izhcayluma) have trail maps. Or just pick a direction and walk the dirt roads going into the countryside. Beautiful. WARNING: Don't take any valuables up the Mandango mountain - many armed robberies have occured there over the years, continuing into July 2011 when a group of tourists were robbed by men with machetes. All other trails appear to be safe.
Rent a mountain bike at El Chino (corner of Diego Vaca de Vega & Jose David Toledo), $8 per day. Ask for a map of where to go. Recommended.
Do a 2 hour, 4 hour, or 1-3 day horse-riding trips. There are quite a few reputable tour operations in town. Tours to Las Palmas cloud forest in the Podocarpus National Park can be arranged through Cabañas Rio Yambala, 4km out of town.
Get a massage, manicure, pedicure or waxi at a few locations in town or at Hosteria Izhcayluma, 2km south of town. Massages at the salon next to Yogurt cafe (just off the main square) are good and cost $10 for one hour. The best massages in town, however, are done by Lola, of Shanta's restaurant/bar (10 minute walk from parque central, on road to Craig's Book Exchange). She only does two per day and appointments are hard to come by, but it's worth the effort. She starts by giving you an all-over assessment of what's needed, then proceeds to give a powerful manipulative massage, incorporating many modalities: chiropractic, Swedish, Eastern styles. She's very empathic and has 14 years experience plus lots of training. She uses hot oil, mmm.. $14 for 80 minutes.
Spend a bucolic afternoon at one of the restaurants around the main plaza.
Yoga, Community Cultural Center (corner of Agua de Hierro and La Paz, 1 block behind Rendez-Vous hotel). 10am-12pm. Tuesdays and Fridays at 10am. Beginning-Intermediate yoga. Mats provided. Nice people, good class. Only $3 for 2 hours!$3. edit
Madre Tierra Resort and Spa (Just north of the river on the hill), 2 km north of Vilcabamba Center, . 8am to 8pm. Full service spa including massage, colon hydrotherapy, reflexology, clay baths, steam baths, manicures, pedicures, facials and jacuzzi. See the website for photos of this very special Oasis in the Andes. Nominated five times for the Best Hotel and Spa in Ecuador by World Travel Awards.varies. edit
Blanca Toledo, Barrio Los Huilcos (Best to take a taxi), ☎ 086951907 or 072640094. Blanca is an experienced masseuse with 20 years of practice in Vilcabamba. She specializes in body massage with a bit of reiki and reflexology. Also offers, colonic hydrotherapy, facial and hair treatments and waxing. Call her in advance for an appointment.edit
Artesanal-Prima Vera-Handicrafts, Sucre st. 10-30 (in front of Hidden Garden Hotel), . AM-PM. Offers locally made souvenirs, recycled paper books and upcycled hand bags and purses in fabric, organic shade-grown coffee, granola, marmalades, beauty products like propolis cream, natural soaps, horse mane gloves, clay, ballon balls, hand-made cards, postcards, mail service/stamps, etc.edit
The Juice Factory: (Located on the central plaza) This is one of the most popular hang-outs for ex-pats. Both, a restaurant, and small health food store, they serve a scrumptious natural breakfast and lunch. All produce is washed before preparation. 9AM-4PM Tues-Sat
Sambucas: (Located on the central plaza) Another popular spot for Europeans and Americans, this restaurant is run by a bilingual staff that serves incredible clean (washed produce) and healthy natural meals for breakfast, lunch and dinner. Their Whole Wheat Crust Vegetarian Pizza is surpassed by none. Hours of operation are variable.
La Terraza: Central Plaza (corner of Diego Vaca de Vega and Bolivar). Serves Mexican and Italian food. Excellent chicken fajitas and nachos. Mains are $3 to $6.
Charlito's: (on Diego Vaca de Vega, above Sucre) Run by a friendly Virginian named Charlie, they have good cheap food and drinks. The veggie sandwich is especially recommended, inexpensive and filling.
Shanta's Bar: Calle Diego Vaca de Vaga, past the bridge, 15 minute walk East of town. Cool atmosphere with a cowboy vibe. Bar seats are horse saddles and the walls are covered in international money, weird animal hides, and neat photos. Serves pizza, filet mignon, and pasta. Good food. Mains $3 to 6$. Large menu of drinks, including their homemade Snake Drink moonshine.
Madre Tierra Restaurant and Bakery, 2 km north of Vilcabamba Center (Just north of the river on the hill), . 8am to 8pm. North American and Ecuadorian home style cooking from scratch with unique ambiance and exceptional views of Mandango and the Valley of Longevity. Some Raw options as the new owners are health minded. They have thrown out the microwaves, aluminum, msg, flouride salt and brought in stainless steel and Vita Mix and Blend Tec blenders! Many ingredients are grown on site in small gardens including local herbs in the Garden of the Elders. Water here is pumped from their own well to insure a great experience inside and outside of your body. A good variety of vegetarian options are available. Featuring Ecuadorian beers, Argentinian and Chilean wines, herbal teas, horchata, local coffee, including simple espresso (European style). Pizza, homemade whole grain breads, cinnamon rolls, banana bread, fresh soups, and the best hamburgers in Southern Ecuador (as voted by Jeff, a local gringo)! This is one Ecuadorian kitchen that you can "inspect" as it is out in the open (nothing to hide here). Several salads on the menu that will delight your eyes and your taste buds as well. Experience this Oasis in the Andes just like Mike Adams the Health Ranger of NaturalNewsdotcom.$2 and up. edit
El Punto, (corner of Sucre & Diego Vaca de Vega). A popular hang-out. Wednesday nights there is an informal poker game amongst the ex-pats who live here. Weekend nights a band usually plays.edit
Charlito's, (just up the block from El Punto). A friendly place to hang out and meet people. Gavin the Kiwi is often here and has many drunken stories to tell.edit
Madre Tierra Smoothie and Pool Bar, 2 km north of Vilcabamba Center (Just north of the river on the hillside), . noon to 9pm. Wide variety of beverages available in the restaurant or beside the pool and fountains set in this beautiful garden setting . From herbal teas, local coffee, and espresso to fresh fruit juices, local beers, imported wines, and liquors, refreshment is experienced at Madre Tierra.edit
Hosteria Ruinas De Quinara (Formerly called Hostel Agua De Hierro) is under new management (same family as former owner), and it's actually a nice place to stay, with swimming pool, jacuzzis, sauna, steam room, bar, all the amenities. Dorm beds for $10, private rooms $15 per person (regardless of one or two full-sized beds in the room). Long-term rentals available for $150/month. You may see reference to a terrible saga of the former owner slipping horse tranquilizers into female resident's drinks, then using his master key to get into their rooms at night and raping them. This repeatedly happened over the course of many years, it was even mentioned in the 2004 Lonely Planet guidebook. See this article  As of early 2009, this man has finally been run out of town, and the police at last have a warrant out for his arrest.
Cabañas Río YambalaSimply the best spot in Vilacabamba, whether you are looking a place to relax for a few weeks during your travels; a retreat in paradise; a place to land, find your feet and get good advice while considering the possibility of settling here; or simply a few days adventure with the best trekking, birding, scenery and access to the Podocarpus National Park in Vilcabamba. Visit waterfalls in Ecuador's most biodiverse cloud forest, lakes in the alpine paramo and our unique Tree Canopy Adventure. Reasonable monthly rates are offered
Hostel Le Rendez-Vous: Calle Diego Vaca de Vega 06-43. Owners are a French couple Isabelle and Serge. Beautiful cabanas around a garden. Very clean, very nice, and lots of hot water. Breakfast is included: home-made bread, eggs or fruit salad, fresh fruit juice, coffee, tea, hot chocolate. 1 person is $15 per night, 2 people are $12 per person per night, and 3 people are $11 per person per night. They have a large collection of DVDs with a portable TV/DVD player ($4/day), hammocks, information booklets on Vilcabamba, Ecuador, and Peru, hiking maps of the area, and WiFi. 
Hostería Izhcayluma: Owners are 2 German brothers, Peter and Dieter. Located about 2KM South of town, overlooking the valley. Different kind of accommodation, surrounded by fantastic tropical gardens. Dormitory bed for $10, double room for $12-15 p.person, single room for $19. Generous buffet breakfast is included: home-made bread, eggs or crepes, fruit salad with home made yogurt and granola, fresh fruit juice, coffee and tea as much as you like, etc. Private cabañas also available for more. A swimming pool and spa services (massages, facials, etc.) are available. Several self guided hiking trails are offered in the Vilcabamba area with excellent maps based on air fotos. The panorama restaurant with great views is also open for lunch and dinner. They have a large collection of DVDs which can be watched, last one starting at 5PM. On-site bar with a pool table and ping pong table opens at 7PM (guests only). There's a community of international travelers to be found. Wi-Fi connection for free. This place is one of a kind and definitely worth a visit, even if only for a meal with the incredible view. However, service can often be on the slow side- you can wait half an hour for a drink from the bar. 
La FloridaLong-term rentals only. Basic but decent one-bedroom duplexes with private bathroom and kitchen for $150/month. Rooms with private bathroom and shared kitchen for $100/month. Room with shared bathroom and shared kitchen for $80/month. Located across the street from Agua de Hierro.
Las Margaritas, (one block south of Church). Probably the best value hotel in town. Nice modern rooms with cable TV and private hot water bathrooms, swimming pool and breakfast included, for only $15 (single) per night! edit
Madre Tierra Resort and Spa, 2 km north of Vilcabamba Center (Just north of the river on the hillside), . checkin: 3pm; checkout: 11:am. A recent guest to this destination Hotel, Spa, Restaurant and Conference Center described his stay here as "just like being on Maui". He was referring to the beautiful, lush vegetation and general feel of this unique jewel in the Andes. At an elevation of 5000 feet, a short distance south of the equator, the consistent Spring-like climate here is conducive to growing delicious organic fruits and vegetables year round. In fact many of the ingredients in Madre Tierra's lobby restaurant are harvested from gardens on site or just down the road. New owners in May of 2010 are health minded and have cleansed the kitchen of aluminum cookware, microwave ovens, fluoride salt and MSG. It is a good start on the way to a goal of exclusively organic fruits, produce and natural meat sources. An oasis on a hill overlooking the Valley of Longevity and Mandango, many guests have a difficult time leaving this special place. The “desert” menu includes a full range of natural, non fattening Spa services that are as memorable as the Bananas Flambé ado. Madre Tierra has been nominated by travel agents five times by the World Travel Awards, Best Hotel and Spa in Ecuador. Free internet in all rooms.$19 and up. edit
Rumi Wilco. This is a protected forest area that can be visited for a walk during the day, and that also offer limited eco-lodging and camping possibilities. The entrance of the reserve is at a 15 minutes walk from the village square (ask for directions). Run by a family of argentinian biologists, this is a place for true lovers of nature. The camping area is 10 minutes away from the main entrance, by a forest path near the river: remember your torch. Prices are 3,50$ per person for camping and 7$ per person for the eco-lodges. They also offer the opportunity of volunteering if you're really interested in getting to know better this magical place; in that case you would help them 4 hours per day and would get a 20% discount on the price of the lodge or camping. edit
Internet - In addition to many local "Cabinas" where computers and WIFI are available for $1/hour, monthly service of a comparable quality (and price) to that of the US is also available, and it is fairly reliable.
Hospitals - There is a small local hospital that is free for everyone. They provide good care for many emergencies, as well as free transportation to Loja for situations they cannot handle.
Pharmacies - There are many small, family-run "Farmacias" in town. Prices are less than US for some things, but more for others. While many US drugs are not available, most common chronic and acute conditions are treatable with available equivalent medications.
Dentists - There are good dentists here and in Loja. Cost of a visit including a filling is about $25.
Veterinarians - There is at least one full time Veterinarian here.
Medical Doctors - there are several general practitioners, a few 'specialty' MDs, and an alternative/homeopathic MD as well, Dr. Diana Armigos, who lives in Loja and comes here during the week. Local Cell #: 098-789-4493
Chiropractors - Currently, there is one Chiropractor, Dr. Jim Braman, a Palmer graduate practicing traditional manipulation. Local Cell #: 098-717-0369 US Skype phone: 919-858-6390
Massage Therapists - There are many practitioners with widely varying techniques and methods. Most have flyers at prominent locations in the town square.
Hypnotherapists - There are local hypnosis practitioners such as, Michael Grady, certified from 4 accredited hypnosis schools for all sorts of applications. US Skype phone: 415-742-8288, website: http://www.YourMindNow.com. Jason Schumacher is also in town.
Alternative Practitioners - Many people with chronic health problems come to Vilcabamba for healing. Modalities of care available include: Acupuncture, Micro-current Therapy, Bio-feedback Therapy, Herbal Therapy, and Reiki, just to name a few.