Exits 62-68 — Walt Disney World Resort — the resort includes 4 amusement parks, 3 water parks, several hotels, a campground, a shopping district, and many restaurants.
Exit 64 — US 192 — leads west to Disney World; east leads through a very commercial area, numerous hotels, Kissimmee, and to Melbourne. Arabian Nights, , is a famous diner show 1/2 mile east of the freeway.
Exit 71 — SeaWorld Orlando, Discovery Cove — marine-life-themed amusement parks offering rides, a water park, and animal shows and exhibits.
Exit 74 — Sand Lake Road — Access to the south end of International Drive. The world's largest McDonald's is located less than a half mile east of the freeway has a massive play area, many video/arcade games, & a McDonald's Bistro serving pasta dishes & fine desserts.
Exits 75A&B — Universal Orlando Resort — 2 amusement parks aimed at youth and young adults as well as a free-admission entertainment and shopping district. Less than 1 mile to the east of this exit is International Drive—a long road known for inexpensive shopping and the Wet-n-Wild waterpark.
Exit 78 — Conroy Road — Holy Land Experience, , best described as a "Christian theme park". On the east side of the interstate lies a large mid to upscale shopping district, including the upscale Mall at Millennia.
Exit 83B — US92/US441/SR50 — heading west (continuing on SR 50) leads to Little Saigon Vietnamese district, Lake County, and the Nature Coast; east leads to Titusville.
Exit 88 — Eatonville — very small town with a long history as an African-American town, home to author Zora Neale Hurston
Exit 108 — CR 4162/Dirkson Drive — heading west leads to the City of DeBary; heading east leads to Deltona and Osteen, and recreation areas at the northern shore of Lake Monroe.
Exit 111 — CR 4146 — heading west leads to Orange City and Blue Spring State Park, where you can watch manatees swim.
Exit 114 — SR 472 — heading west leads to Cassadaga Spritualist Camp.
Exit 116 — CR 4116 — heading east leads to Lake Helen;
Exit 118 — SR 44 — heading west leads to Stetson University in downtown DeLand and eventually Lake Woodruff National Wildlife Refuge; heading east leads to the Volusia County Fair and Expo Center, the New Smyrna Speedway and New Smyrna Beach.
Exit 129 — US 92 — heading west leads to Tiger Bay State Forest; heading east leads to LPGA International Golf Club and Daytona International Speedway in Daytona Beach.