Talkeetna - The closest major town to Mt. McKinley, a 2.5 hour drive north of Anchorage and jump-off point for Denali mountain climbers & flight-seeing.
Valdez - Farthest north ice-free port in the US and is at the beginning of the Richardson Highway. The terminus of the Trans-Alaska Pipeline (formerly Alyeska Pipeline).
Wasilla - originally was a stop on the highway at Teeland's General store, but started developing in the 1970's after the Parks Highway was built, and has become a well-established town.
Whittier (Alaska) - A seaport on the western side of Prince William Sound, just 60 miles from Anchorage and connected to it by road and train through a mountain tunnel. Was also a major military port during World War II and the barracks are some of the few buildings there.
Willow - This town is now the beginning of the famous Iditarod Race, after it's official start in Anchorage.
Visitors will most likely arrive at Ted Stevens International Airport in Anchorage (ANC). From Anchorage, the highway goes in two directions, either south to the Kenai Peninsula or north to the MatSu Valley (Palmer and Wasilla), where the road splits into either the Parks Highway (Denali, Fairbanks) or the Glenn Highway (Glennallen, Canada). The Alaska Railroad (http://www.akrr.com/) runs passenger trains to Seward on the Kenai Peninsula in the summer and north to Fairbanks year round. There are plenty of rental car agencies in Anchorage, but it is important to book ahead in the high season. There is a bus service south to the Kenai (http://www.homerstageline.com/) year round. There is public transportation in Anchorage (People Mover: http://www.muni.org/transit1/index.cfm) and Fairbanks.