Santo Domingo de los Colorados
There are several buses hourly to and from Quito (3 hour and about $2.50).
Hotel Patricia, opposite to the bus station, offers budget rooms for those travellers who need to stay the night waiting for their connection. Single/double $5/$10.
The bus terminal is surrounded by hotels within walking distance.
The Grand Hotel Santo Domingo is about 5 minutes away by taxi. It is a higher end hotel in the area with a pool and put-put golf course. Rooms around $60/night.