Santarém is about 36 hours by river boat from Manaus and a couple of days from Belem, making it an ideal place for a few days' stopover on a trip along the Amazon. Boats leave Manaus every day besides Sunday. There are usually 3 boats leaving from Manaus, however on Wednesdays only one boat leaves and costs R10 more than usual for first class. Usual cost is about R110-120 for first class (top deck with a hammock.)
There's a domestic airport(Santarém-Maestro Wilson Fonseca Airport), but few foreign travelers use it to get in. It's handy if the Amazon gets to you and you need a quick ride out, though.
A few bar-come restaurants along the Beira Rio, particularly downstream from the center.
There is free wifi available at Praça da Matriz.
Santarém has two ports: Docas do Pará serves farther destination like Manaus and Belém while a smaller port near Praça Tiradentes serves destinations on the Tapajós river and other local destinations like Monte Alegre and Alenquer.