Puerto Ayacucho is a city in Guayana.
Take a flight from Maiquetía. the ticket costs BsF 800 (2010), around 100€.
There is an hair dresser along the avenida orinoco, on the left hand side as you walk towards to the airport, that offers combined transport to San Fernando de Atabapo (by road up to Samariapo or Morganito, then by river). it leaves at 7:00 in the morning and costs BsF 70 (2010, 9€). this could be a good way to get to Puerto Inírida, in Colombia.