Laramie is located at very high altitude (7,200+ ft) and due to this has considerably milder summer summers and more fierce winters than other US cities of comparable latitude in the upper Midwest. This also means that the climate around Laramie is very dry most of the year so travelers here should take care to drink lots of fluid and not over exert themselves immediately upon arrival to mitigate potential altitude sickness risks.
The primary access to Laramie is along US Interstate 80, the main east west corridor in the state. Because of the altitude and northern location, it is important to be aware of road conditions and road closures along all roads but especially I-80 as its closure can strand you. Road conditions are available on the internet at several sources including this one: 
In the summer months the town is also easily accessible on a smaller road (US 287) that comes up from Fort Collins, Colorado.
Laramie Regional Airport (LAR), . SU-F: 5:30AM-9PM, Sa: 6AM-9PM. Daily commercial flights to Denver. LAR is also a general aviation airport with rentable hangar space, aviation and jet fuel, and two courtesy cars.edit
Laramie is also accessible from Denver International Airport. From Denver, take Interstate 25 north to Cheyenne, where it intersects Interstate 80.
Hertz, 555 General Brees Rd, ☎ +1 307 745-0500. M-W 7AM-5:30PM,7PM-8PM; Th 7AM-5:30PM, F 7AM-5PM, Sa 9AM-12 noon, Su 3:30PM-5PM, 7PM-8PM. Flights will be met after hours with 24 hours advance notice. After hours return is available in Hertz lot via drop-box.edit
Enterprise, 2208 E. Grand Ave, ☎ +1 307 721-9876. M-F: 7:30AM-5PM; Sat: 8:30-12 noon; Su: Closed. edit
Wyoming Territorial Prison State Historic Site, 975 Snowy Range Road, ☎ +1 307 745-6161, . Daily: 9AM-6PM, call for winter hours. This prison, now a state historic site, opened in the late 19th century held some of the regions most hardened criminals.Adults: $5.00, 12-17: $2.50, 11 and under: Free. edit
Snowy Range Scenic Byway, . A nationally designated scenic byway, Snowy Range Road is a 29 mile (46 km) drive from Laramie to Saratoga via Snowy Range Pass. There is fishing, picnicing, and hiking opportunities along the road, including a half-day hike to the top of 12,013 ft (3,661 m) Medicine Bow Peak. The pass is closed in winter.edit
Fox Run Steakhouse (Laramie Country Club), 489 HWY 230, ☎ 307-745-4161, . Exceptional steaks, variety of non-beef entrees including lamb and buffalo, full bar, extensive drink and wine list. Great prices. Online menu. Available for parties. Open Monday - Saturday 5:00pm - 9:00pm. edit
1st Inn Gold, 421 Boswell (Jct. 287 & I-80), ☎ +1 307 742-3721 (fax: +1 307 742-5473), . King, Queen & Double Rooms (Smoking & Non Smoking). Free Continental breakfast, parking, and local calls. Cable TV with HBO. Outdoor Pool, Indoor Hot Tub.edit
Albany Lodge, 1148 Highway 11, ☎ +1 307 745-5782 (firstname.lastname@example.org, fax: +1 307 745-8738), . Rooms, suites, and cabins. Restaurant on site. ATV and snowmobile rentals.$85-315. edit
Baymont Inn and Suites, ☎ +1 307 742-6665 (fax: +1 307 742-9193). checkin: 2PM; checkout: 11AM. edit
Best Value Inn, I-80/Snowy Range Rd., ☎ +1 307 721-8860. edit
Comfort Inn, 3420 Grand Ave, ☎ +1 307 721-8856 (fax: +1 307 721-5166), . checkin: 3PM; checkout: 11AM. Fitness center, indoor heated pool and hot tub. Free continental breakfast, local calls, weekday newspaper, and coffee.edit
Days Inn, 1368 McCue Street, ☎ +1 866 644-5685 (email@example.com, fax: +1 307 742-8934), . Guestrooms and suitesg with microwaves, cable television, and free high–speed wireless Internet access. Indoor pool, activity desk, fitness equipment, and business center. Free Continental Breakfast. Pet allowed in Smoking Rooms for additional fee.edit
Econo Lodge, 1370 McCue St, ☎ +1 307 745-8900 (fax: +1 307 745-5806), . checkin: 2PM; checkout: 11AM. Indoor heated pool and game room. Free continental breakfast and wireless high-speed Internet access.edit
Gas Lite Motel, 960 N. 3rd, ☎ +1 800 942-6610. Indoor pool. Continental breakfast. Pets allowed.edit
Hampton Inn, 3715 E. Grand Ave, ☎ +1 307 742-0125 (fax: +1 307 742-0126), . checkin: 3PM; checkout: 11AM. edit
Holiday Inn, 204 S 30th St, ☎ +1 307 721-9000 (fax: +1 307 721-9015), . checkin: 3PM; checkout: 12 noon. Opened in 2007, this hotel caters to the higher-end and business traveller with king, double queen, and suites. All rooms have a 32" (81 cm) flat screen TV with AM/FM Clock Radio and MP3 docking station, microwave, and fridge. The hotel also has a business center, indoor pool and whirlpool, fitness center, and wireless and hard wired internet.edit