It's only about an hour away from Boston on I-95 (in good traffic, of course), or a more leisurely, scenic drive on Route 1. The outlet store district is on Route 1, a half-mile north of I-95 (take Exit 3 from the highway).
Beware toll roads in nearby New Hampshire. The highways leading to and from the New Hampshire coast get crowded during good beach weather.
Kittery Outlets, . Kittery has over 30 national major-brand clothing stores (including maternity, children's clothing, accessories, lingerie, and hosiery), over 20 shoe stores, and a reasonable selection of "active wear" and sports gear. There are over two dozen stores with housewares, plus a handful of miscellaneous outlets (candy, toys, jewelry) and services (fuel, restrooms, phones, banking, coffee, welcome center, etc.).edit
Kittery Trading Post, 301 U.S. Route One, ☎ +1-888-KTP-MAINE (587-6246), . Established in 1938, this store has three floors containing the largest selection of outdoor items in New England.edit
Mostly Maine, 40 US Route One, . Features thousands of items produced in Maine.edit
Bob's Clam Hut, 315 US Route 1, ☎ +1-207-439-4233, . Offers an excellent lobster roll the way it should be served as well as (obviously) excellent fried clams. Food is served from a pickup window with both indoor and outdoor seating area. This restaurant has been around since 1956 and features a bit of New England atmosphere in addition to good food.$10-$20 for most items. edit
Robert's Maine Grill, 326 Route 1, ☎ +1-207-439-0300 (fax: +1-207-439-2447), . Large classic Maine restaurant with an updated menu. Features a deck and a raw bar. $13-25 per item. edit
Warren's Lobster House. Touts its salad bar as "the seacoast's best". Try the 'Super Bowl of Chowder' (Clam chowder with shrimp, scallops, and lobster).edit
The Weathervane. The first restaurant in the regional chain, as well as its primary shipping point.edit
Morrisons Lobsters, 11 Badgers Island West, ☎ (207) 439-2501. Lobsters, clams, and steamers. Fresh, local, cheap, BYOB. Their seafood is served on a deck overlooking the Piscataqua river, with a terrific view of nearby Portsmouth.edit